Document Detail


Kinetics and distribution of bovine gammadelta T-lymphocyte in the intestine: gammadelta T cells accumulate in the dome region of Peyer's patch during prenatal development.
MedLine Citation:
PMID:  15752551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kinetics and distribution of gammadelta T cells in bovine intestine including jejunal and ileal Peyer's patch were examined. The number of gammadelta T cells increased significantly in the dome region during prenatal development, but decreased notably after birth. The number of some gammadelta T cells, CD4+ cells, and CD8+ cells in the intestinal villi remained constant during prenatal development, but increased significantly after birth. The kinetics of the gammadelta T cells in the dome region during prenatal development were quite distinct from those of the gammadelta T cells, CD4+ cells, and CD8+ cells in the intestinal villi. In the fetal ileum at full-term gestation, the frequencies of expression of the T-cell receptor gamma variable region (TCR Vgamma) family were TCR Vgamma1 (48%), Vgamma2 (4%), and Vgamma5 (48%). However, in 2-month-old calf ileum, TCR Vgamma5 (90%) was dominant. We speculate that functional differences exist between gammadelta T cells in the dome region during prenatal development and in the intestinal villi after birth.
Authors:
Masahiro Yasuda; Daisuke Ogawa; Tetsuo Nasu; Takahiro Yamaguchi; Takayuki Murakami
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-25
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  29     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  555-64     Citation Subset:  IM    
Affiliation:
Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan. yasudaja@cc.miyazaki-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
CD4-Positive T-Lymphocytes / cytology,  immunology*
CD8-Positive T-Lymphocytes / cytology,  immunology*
Cattle
Female
Fetal Development / immunology*
Fetus / immunology
Fluorescent Antibody Technique / veterinary
Immunoglobulin Variable Region / immunology
Immunohistochemistry / veterinary
Intestines / cytology,  immunology*
Kinetics
Peyer's Patches / cytology,  embryology*,  immunology*
Pregnancy
RNA / chemistry,  genetics
Receptors, Antigen, T-Cell, gamma-delta / genetics,  immunology*
Reverse Transcriptase Polymerase Chain Reaction / veterinary
Chemical
Reg. No./Substance:
0/Immunoglobulin Variable Region; 0/Receptors, Antigen, T-Cell, gamma-delta; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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