| Kinetics and distribution of bovine gammadelta T-lymphocyte in the intestine: gammadelta T cells accumulate in the dome region of Peyer's patch during prenatal development. | |
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MedLine Citation:
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PMID: 15752551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kinetics and distribution of gammadelta T cells in bovine intestine including jejunal and ileal Peyer's patch were examined. The number of gammadelta T cells increased significantly in the dome region during prenatal development, but decreased notably after birth. The number of some gammadelta T cells, CD4+ cells, and CD8+ cells in the intestinal villi remained constant during prenatal development, but increased significantly after birth. The kinetics of the gammadelta T cells in the dome region during prenatal development were quite distinct from those of the gammadelta T cells, CD4+ cells, and CD8+ cells in the intestinal villi. In the fetal ileum at full-term gestation, the frequencies of expression of the T-cell receptor gamma variable region (TCR Vgamma) family were TCR Vgamma1 (48%), Vgamma2 (4%), and Vgamma5 (48%). However, in 2-month-old calf ileum, TCR Vgamma5 (90%) was dominant. We speculate that functional differences exist between gammadelta T cells in the dome region during prenatal development and in the intestinal villi after birth. |
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Authors:
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Masahiro Yasuda; Daisuke Ogawa; Tetsuo Nasu; Takahiro Yamaguchi; Takayuki Murakami |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-25 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: 29 ISSN: 0145-305X ISO Abbreviation: Dev. Comp. Immunol. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-03-08 Completed Date: 2005-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 555-64 Citation Subset: IM |
Affiliation:
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Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan. yasudaja@cc.miyazaki-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD4-Positive T-Lymphocytes / cytology, immunology* CD8-Positive T-Lymphocytes / cytology, immunology* Cattle Female Fetal Development / immunology* Fetus / immunology Fluorescent Antibody Technique / veterinary Immunoglobulin Variable Region / immunology Immunohistochemistry / veterinary Intestines / cytology, immunology* Kinetics Peyer's Patches / cytology, embryology*, immunology* Pregnancy RNA / chemistry, genetics Receptors, Antigen, T-Cell, gamma-delta / genetics, immunology* Reverse Transcriptase Polymerase Chain Reaction / veterinary |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Variable Region; 0/Receptors, Antigen, T-Cell, gamma-delta; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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