Document Detail


Kinetics and disposition of fluorescein-labelled liposomes in healthy human subjects.
MedLine Citation:
PMID:  3203707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vivo kinetics and organ uptake of multilamellar liposomes have been studied in healthy volunteers. Sodium fluorescein-containing liposomes composed of equimolar amounts of egg phosphatidylocholine and cholesterol were injected into a peripheral vein in 4 healthy subjects. Blood samples collected from the femoral artery, hepatic vein and pulmonary artery, were analysed for liposomal dye content. The results, showing involvement of the reticuloendothelial system (RES) in the removal of liposomes, confirmed those previously obtained with radiolabelled preparations. Use of an innocuous liposomal marker (sodium fluorescein) and conventional vascular catheterization techniques, as employed here, may provide a reliable and clinically acceptable approach to establishing disease-induced changes in the kinetics of uptake of drug-containing liposomes by the RES, and thus help in the design of protocols for effective treatment.
Authors:
H G Eichler; J Senior; A Stadler; S Gasic; P Pfundner; G Gregoriadis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  34     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-03     Completed Date:  1989-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  475-9     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology, I. Medizinische Universitätsklinik, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Fluoresceins / diagnostic use*
Humans
Liposomes / pharmacokinetics*
Lung / metabolism
Male
Tissue Distribution
Chemical
Reg. No./Substance:
0/Fluoresceins; 0/Liposomes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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