Document Detail

Kinetics of disopyramide after intravenous infusion to patients with myocardial infarction and heart failure.
MedLine Citation:
PMID:  4024955     Owner:  NLM     Status:  MEDLINE    
Total body clearance, half-life and volume of distribution of disopyramide (Norpace, Searle G.D.) was measured during a six to eight hour infusion to steady state in twenty four patients with either congestive heart failure or acute myocardial infarction and compared to eleven patients without these diseases. All patients were given a bolus injection of 150 mg disopyramide followed by a continuous infusion of 18-24 mg per hour. Serum concentration of disopyramide and its main dealkylated metabolite were determined by HPLC. The clearance in patients without myocardial infarction or congestive heart failure was 1.71 +/- 0.60 ml/min./kg (mean +/- S.D.), not significantly different from those who had either myocardial infarction, congestive heart failure or both. Half-life was 798 min. in patients without heart failure, not significantly different from the values in the other groups. The ratio between disopyramide and its metabolite varied between 3 to 10. Twenty-six % of the steady state serum concentrations of disopyramide were outside the recommended therapeutic range (2-5 micrograms/ml), but no adverse haemodynamic effects were observed in any of the patients. The suggested dosage regimen of disopyramide seems to result in a satisfactory response.
J Bonde; H R Angelo; S Bødtker; T L Svendsen; J P Kampmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  56     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-09-04     Completed Date:  1985-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  278-82     Citation Subset:  IM    
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MeSH Terms
Disopyramide / metabolism*
Heart Failure / metabolism*
Metabolic Clearance Rate
Middle Aged
Myocardial Infarction / metabolism*
Reg. No./Substance:

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