Document Detail

Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid.
MedLine Citation:
PMID:  2422427     Owner:  NLM     Status:  MEDLINE    
In vivo treatment of randombred Swiss Webster mice with polyriboinosinic-polyribocytidylic acid (poly l X poly C) inhibited the induction of cytochrome P-450's by both 3-methylcholanthrene [(MCA) CAS: 56-49-5] and phenobarbitol [(PB) CAS: 50-06-6]. Concomitant treatments with poly l X poly C and a single dose of MCA inhibited the induction of P-450's for 24 hours and delayed the obtainment of the MCA-induced P-450 levels for approximately 48-72 hours. When cytochrome P-450 levels were induced by four successive daily treatments of MCA or PB and when poly l X poly C was given on only the 1st day, induction of P-450's was completely suppressed for 24 hours and obtainment of the maximal P-450 level was delayed by 72-96 hours. Treatment with poly l X poly C of animals preinduced for P-450's by four successive daily treatments with either PB or MCA decreased the P-450 content to the noninduced basal level within 24 hours. The effect was temporary in the MCA-treated mice since P-450 content recovered to the MCA-preinduced levels within 72 hours. PB-dependent P-450 induction was short lived, and no recovery occurred after poly l X poly C treatment of PB-preinduced mice. Reduced hepatic cytochrome P-450 contents correlated with decreased abilities of liver homogenates to metabolically activate benzo [a]pyrene (CAS: 50-32-8) and N-acetyl-2-aminofluorene (CAS: 53-96-3), as scored in an Ames Salmonella typhimurium revertant assay.
D O Crowe; J J Reiners; D E Nerland; G Sonnenfeld
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  76     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-11     Completed Date:  1986-06-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  879-83     Citation Subset:  IM; S    
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MeSH Terms
Cytochrome P-450 Enzyme System / analysis*
Enzyme Induction / drug effects
Interferons / pharmacology
Liver / drug effects,  enzymology*
Methylcholanthrene / pharmacology
Mutagens / metabolism
Poly I-C / pharmacology*
Substrate Specificity
Grant Support
Reg. No./Substance:
0/Mutagens; 24939-03-5/Poly I-C; 56-49-5/Methylcholanthrene; 9008-11-1/Interferons; 9035-51-2/Cytochrome P-450 Enzyme System

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