Document Detail

Kinetics of cytokines and PMN-E in thoracoscopic esophagectomy.
MedLine Citation:
PMID:  11965470     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Perioperative increases in the levels of cytokines and polymorphonuclear leukocyte elastase (PMN-E) have been shown to be related to degree of surgical trauma. METHODS: We measured the changes in levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and PMN-E in the perioperative period in patients undergoing thoracoscopic esophagectomy (n = 15) and conventional transthoracic esophagectomy (n = 15) for thoracic esophageal cancer. RESULTS: Both IL-6 and IL-8 increased markedly immediately after transthoracic esophagectomy and thereafter, but only a slight increase was observed after the thoracoscopic procedure (IL-6: p = 0.047; IL-8: p = 0.03). A difference was also seen in the pattern of changes in PMN-E. Levels of PMN-E increased immediately after transthoracic esophagectomy and continued to be high up to the 3rd postoperative day, but they remained low after the thoracoscopic procedure and showed no increase (p <lt; 0.01). CONCLUSION: These results suggest that, compared with transthoracic esophagectomy, thoracoscopic esophagectomy results in less production of cytokines and PMN-E and thus causes less surgical trauma.
T Fukunaga; A Kidokoro; M Fukunaga; K Nagakari; M Suda; S Yoshikawa
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgical endoscopy     Volume:  15     ISSN:  1432-2218     ISO Abbreviation:  Surg Endosc     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-04-19     Completed Date:  2002-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1484-7     Citation Subset:  IM    
Department of Surgery, Urayasu Hospital of Juntendo University, School of Medicine, 2-1-1, Tomioka, Urayasu-shi, Chiba 279-0021, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cytokines / biosynthesis,  blood*
Esophageal Neoplasms / surgery
Esophagectomy / methods*
Interleukin-6 / blood
Interleukin-8 / blood
Leukocyte Elastase / biosynthesis,  blood*
Leukocytes / enzymology,  metabolism
Middle Aged
Perioperative Care
Postoperative Period
Thoracoscopy / methods*
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/Interleukin-8; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optimal positive end-expiratory pressure (PEEP) settings in differential lung ventilation during sim...
Next Document:  Pancreatic injury: an unusual complication of laparoscopic cholecystectomy.