Document Detail


Kinetics of carbamazepine and its 10,11-epoxide metabolite in children.
MedLine Citation:
PMID:  1261166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The plasma steady-state concentration of carbamazepine (CBZ) and its metabolite (carbamazepine-10,11-epoxide, CBZ-epoxide) was assessed in 43 children (2-15 yr) on CBZ (Tegretol) treatment. Twenty of the children received combined treatment with other anticonvulsant drugs simultaneously. The plasma concentrations were in the same range as had been found in adult patients on corresponding doses. Only a weak correlation was noted between dose and plasma CBZ concentration in the group of children on single-drug treatment, and there was no correlation in the group of children on combined drug regimen. Plasma levels of CBZ correlated with those of the metabolite. Children on combined treatment had lower CBZ concentration and, expressed as percent of the parent drug, the metabolite concentration was significantly higher than in children treated only with CBZ. In 2 children the plasma half-life of CBZ was estimated and found to be slightly shorter than has previously been reported in adults. In evaluating the plasma level-effect relationship of CBZ, the plasma concentration of the CBZ-epoxide should be measured simultaneously because of its anticonvulsant effect and interindividual variability.
Authors:
A Rane; B Höjer; J T Wilson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  19     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  276-83     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Carbamazepine / analogs & derivatives*,  metabolism*,  therapeutic use
Child
Child, Preschool
Dose-Response Relationship, Drug
Drug Therapy, Combination
Epilepsy / drug therapy
Epoxy Compounds / metabolism
Female
Half-Life
Humans
Infant
Male
Chemical
Reg. No./Substance:
0/Epoxy Compounds; 298-46-4/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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