Document Detail


Kinetics of both leukemic and normal cell population reduction following 5-azacytidine.
MedLine Citation:
PMID:  50128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytotoxic effect of 5-azacytidine (AzaCR) on normal hematopoietic colony-forming units (NCFU) and L1210 leukemic colony-forming units (LCFU) in the femoral marrow of BALB/c x DBA/2 F1 mice was studied using the spleen colony assay. Dose-survival curves for LCFU and NCFU were biphasic. Repopulation of LCFU was rapid at a low dose of AzaCR (0.1 mg/mouse) but was delayed for greater than 6 days at higher doses (0.25 mg/mouse and above). Of the agents tested in this system, only AzaCR exhibited these properties. Survival of mice with L1210 leukemia following AzaCR administration was prolonged beyond that predicted by the degree of LCFU reduction alone, and reflected the delay in LCFU repopulation. In contrast, repopulation of NCFU in normal mice was not delayed at a high dose of AzaCR (0.5 mg/mouse). AzaCR produced a nine-fold greater reduction of NCFU in leukemic mice than in normal mice, measured 5 days after AzaCR injection. While divided doses of AzaCR produced LCFU cytotoxicity equivalent to a single dose, 24-hr infusions of high doses were inferior to single infections.
Authors:
C A Presant; T Vietti; F Valeriote
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  35     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-10-30     Completed Date:  1975-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1926-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Azacitidine / pharmacology,  therapeutic use*,  toxicity
Bone Marrow / drug effects
Bone Marrow Cells
Dose-Response Relationship, Drug
Femur
Hematopoietic Stem Cells / drug effects*
Kinetics
Leukemia L1210 / drug therapy*
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Time Factors
Chemical
Reg. No./Substance:
320-67-2/Azacitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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