| Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation. | |
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MedLine Citation:
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PMID: 14656753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergen inhalation is associated with increased eosinophil/basophil progenitors in bone marrow 24 hours after allergen inhalation. This study examined the kinetics of eosinophilopoiesis in dual (n = 14), compared with isolated early, responders (n = 12). Dual responders, in contrast to isolated early responders, develop significant sputum and blood eosinophilia and prolonged airway hyperresponsiveness. Bone marrow aspirates were taken before and 5, 12, 24, and 48 hours after allergen inhalation. In dual responders, increases in interleukin (IL)-3-responsive progenitors were detected as early as 5 hours after allergen inhalation, and IL-5-responsive progenitors were detected at 12 and 24 hours. No changes were detected in isolated early responders. Bone marrow IL-5 protein levels increased at 12 and 24 hours in dual responders only and these increases correlated with increases in IL-5-responsive progenitors. In addition, bone marrow IFN-gamma levels increased in dual responders at 48 hours. These data demonstrate that, in dual responders, there is allergen-induced activation of an eosinophilopoietic process that is rapid and sustained, and a relationship between increased bone marrow IL-5 levels and increased eosinophil production. We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors. |
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Authors:
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Sandra C Dorman; Roma Sehmi; Gail M Gauvreau; Rick M Watson; Ronan Foley; Graham L Jones; Judah A Denburg; Mark D Inman; Paul M O'Byrne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-12-04 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 169 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-25 Completed Date: 2004-03-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 565-72 Citation Subset: AIM; IM |
Affiliation:
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Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Allergens / adverse effects, immunology Asthma / blood, complications, immunology* Bone Marrow / chemistry, immunology* Bronchial Hyperreactivity / complications, immunology Bronchial Provocation Tests Cytokines / analysis, blood, immunology* Eosinophils / immunology* Female Forced Expiratory Volume Hematopoiesis / immunology* Hematopoietic Stem Cells / immunology Humans Hypersensitivity, Immediate / complications Inflammation Interferon-gamma / immunology Interleukin-10 / immunology Interleukin-3 / immunology Interleukin-5 / immunology Leukocyte Count Male Middle Aged Pulmonary Eosinophilia / etiology, immunology* Sputum / chemistry, immunology Time Factors Up-Regulation / immunology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Cytokines; 0/Interleukin-3; 0/Interleukin-5; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
Comment In:
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Am J Respir Crit Care Med. 2004 Mar 1;169(5):549-50
[PMID:
14982817
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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