Document Detail

Kinetics of amorolfine in human nails.
MedLine Citation:
PMID:  8366874     Owner:  NLM     Status:  MEDLINE    
Amorolfine penetrates rapidly into the nail after topical application. The kinetics of penetration follow an exponential law as expected, and the level of amorolfine measured in the nail (at least in the upper levels) already exceeds the MIC of most fungi causing onychomycosis after only 24 h of contact. After topical application amorolfine is detectable in the nail earlier and in higher concentrations than terbinafine and itraconazole after oral application.
A Polak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mycoses     Volume:  36     ISSN:  0933-7407     ISO Abbreviation:  Mycoses     Publication Date:    1993 Mar-Apr
Date Detail:
Created Date:  1993-10-07     Completed Date:  1993-10-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  101-3     Citation Subset:  IM    
F. Hoffmann-La Roche Ltd, Pharma Division, Preclinical Research, Basel, Switzerland.
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MeSH Terms
Administration, Topical
Antifungal Agents / pharmacokinetics*
Morpholines / pharmacokinetics*
Nails / metabolism*
Reg. No./Substance:
0/Antifungal Agents; 0/Morpholines; 67467-83-8/amorolfine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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