Document Detail

Kinetics of 131I-beta2 microglobulin in hemodialysis patients: assessment using total body counting.
MedLine Citation:
PMID:  9684694     Owner:  NLM     Status:  MEDLINE    
The kinetics of 131I-beta2-microglobulin (beta2-M) were studied using external total body gamma counting in a low noise chamber after administration of trace doses of radioactivity (4 microCi) in 14 uremic patients treated by either hemodialysis or hemofiltration. Data were collected over a 1 week period that included 3 dialysis sessions. The following artificial membranes were used: Cuprophan, polyacrylonitrile AN69, polysulfone, polymethylmethacrylate (PMMA), and polyamide. Radiolabeled beta2-M excretion by an extrarenal route was nearly nonexistent. The 131I-beta2-M half-life was between 2.4 and 8 days, shorter in patients with residual diuresis. A mean removal of 153+/-33 mg/L of beta2-M was obtained per dialysis session with a highly permeable membrane. A hemofiltration session (25 L exchange per session) was slightly more efficient in removing beta2-M than a 4 h hemodialysis session with the same AN69 highly permeable membrane. The amounts of 131I-beta2-M binding on the membranes, expressed as beta2-M equivalents, were 0, 16, 54, 58, and 59 mg/m2 for Cuprophan, polysulfone, polyacrylonitrile AN69, polyamide, and PMMA, respectively. In conclusion, the decrease of total body gamma counting directly reflected the beta2-M breakdown and removal in hemodialysis patients. Intact beta2-M was removed by convection with synthetic, highly permeable membranes. In addition, membrane adsorption accounted for 15% (polysulfone) to near 100% (PMMA) of the beta2-M removal per session. Adsorption was of the same magnitude regardless of the dialysis technique in use, indicating a membrane saturability process. None of the currently available dialysis procedures based on a 3 sessions per week schedule can balance beta2-M generation.
J Chanard; V Caudwell; J Valeire; C Vincent; C Randoux; A Wuillai; A Wynckel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  22     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-01     Completed Date:  1998-10-01     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-80     Citation Subset:  IM    
Service de Néphrologie, Centre Hospitalier et Universitaire, Reims, France.
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MeSH Terms
Acrylic Resins / chemistry
Acrylonitrile / analogs & derivatives,  chemistry
Biocompatible Materials / chemistry
Cellulose / analogs & derivatives,  chemistry
Hemofiltration* / instrumentation
Iodine Radioisotopes / diagnostic use*
Membranes, Artificial
Middle Aged
Nylons / chemistry
Polymers / chemistry
Polymethyl Methacrylate / chemistry
Radiopharmaceuticals / diagnostic use*
Renal Dialysis* / instrumentation
Sulfones / chemistry
Uremia / therapy
Whole-Body Counting*
beta 2-Microglobulin / chemistry,  pharmacokinetics*
Reg. No./Substance:
0/Acrylic Resins; 0/Biocompatible Materials; 0/Iodine Radioisotopes; 0/Membranes, Artificial; 0/Nylons; 0/Polymers; 0/Radiopharmaceuticals; 0/Sulfones; 0/beta 2-Microglobulin; 107-13-1/Acrylonitrile; 25014-41-9/polyacrylonitrile; 25135-51-7/polysulfone P 1700; 60650-36-4/AN-69; 9004-34-6/Cellulose; 9011-14-7/Polymethyl Methacrylate; 9050-09-3/cuprammonium cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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