| Kinetic study of γ-hexabromocyclododecane orally given to laying hens (Gallus domesticus) : "Transfer of HBCD in laying hens" | |
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MedLine Citation:
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PMID: 21808974 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: High concentrations of hexabromocyclododecane (HBCD) sometimes recorded in free-range hens' eggs are thought to be due to soil ingestion. Of the three stereoisomers of HBCD (α-, β-, and γ-HBCD), γ-HBCD is the main component in the commercial mixture, as well as in environmental matrices, whereas the isomer profile is α-dominated in biota. In fish and in mammals, this shift is thought to be due to a rapid elimination of γ-HBCD and to its bioisomerization to the more persistent α-HBCD. The aim of the current controlled study was to better understand the fate of ingested HBCD in laying hens. The isomer profile in soil being γ-dominated, excretion kinetics of γ-HBCD into egg yolk, and accumulation in liver and in abdominal fat were investigated. MATERIALS AND METHODS: Forty-eight laying hens were individually housed and fed with a spiked diet containing 1.1-ng γ-HBCD per gram for 21 days and with a clean diet for the following 18 days. Hens were sequentially slaughtered throughout the 39-day experiment. α-, β-, and γ-HBCD were analyzed in egg yolk, in abdominal fat, and in liver by LC-MS/MS. α- and γ-HBCD were quantified in the three tissues, while β-HBCD was never quantified. RESULTS AND CONCLUSION: Kinetics of the two isomers suggests that γ-HBCD is rapidly biotransformed and eliminated, and partly isomerized into the more persistent α-HBCD. Carry-over rate of ingested γ-HBCD to egg yolk was estimated at 1.2%. Estimated half-lives of γ-HBCD in egg yolk, in abdominal fat, and in liver were 2.9, 13, and 0.41 days, respectively. |
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Authors:
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Agnès Fournier; Cyril Feidt; Philippe Marchand; Anaïs Vénisseau; Bruno Le Bizec; Nadine Sellier; Erwan Engel; Jérémy Ratel; Angélique Travel; Catherine Jondreville |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-2 |
Journal Detail:
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Title: Environmental science and pollution research international Volume: - ISSN: 1614-7499 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441769 Medline TA: Environ Sci Pollut Res Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), Nancy Université, INRA, ENSAIA, 2 avenue de la Forêt de Haye, BP 172, 54505, Vandoeuvre-lès-Nancy, France, agnes.fournier@ensaia.inpl-nancy.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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