| Kinetic study of glomerular cells of diabetic rats in relation to the development of irreversible glomerular sclerosis. | |
MedLine Citation:
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PMID: 1770014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to clarify the cellular kinetics involved in progression of diabetic glomerulosclerosis, the epithelial cells of spontaneously diabetic WBN/Kob rats were investigated by labeling with the DNA precursor bromodeoxyuridine, which was histochemically stained using monoclonal antibody. The labeling index (number of labeled cells/number of cells counted) of glomeruli was constantly low (approximately 0.15%) and no significant variation could be demonstrated in control rats of the Wistar strain. In both control and diabetic rats, podocytes showed no evidence of mitosis. In contrast to capillary podocytes, the Bowman epithelial cells of diabetic rats showed increased labeling, often surrounding sclerotic capillaries. These observations suggest a critical role of Bowman's epithelial cells in the development of irreversibly sclerotic glomeruli in diabetic nephropathy. |
Authors:
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G Osawa; T Sasaki; T Sato; M Yamada; Y Kitano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of diabetic complications Volume: 5 ISSN: 0891-6632 ISO Abbreviation: J Diabet Complications Publication Date: 1991 Apr-Sep |
Date Detail:
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Created Date: 1992-02-21 Completed Date: 1992-02-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8708656 Medline TA: J Diabet Complications Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 115-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine (Nephrology Section), Kawasaki Medical School, Kurashiki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / pathology, ultrastructure Diabetes Mellitus, Experimental / pathology*, physiopathology Diabetic Nephropathies / pathology*, physiopathology Glomerular Mesangium / pathology, ultrastructure Kidney Glomerulus / blood supply, pathology*, ultrastructure Kinetics Microscopy, Electron Rats Rats, Inbred Strains |
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