Document Detail

Kinetic study of glomerular cells of diabetic rats in relation to the development of irreversible glomerular sclerosis.
MedLine Citation:
PMID:  1770014     Owner:  NLM     Status:  MEDLINE    
In order to clarify the cellular kinetics involved in progression of diabetic glomerulosclerosis, the epithelial cells of spontaneously diabetic WBN/Kob rats were investigated by labeling with the DNA precursor bromodeoxyuridine, which was histochemically stained using monoclonal antibody. The labeling index (number of labeled cells/number of cells counted) of glomeruli was constantly low (approximately 0.15%) and no significant variation could be demonstrated in control rats of the Wistar strain. In both control and diabetic rats, podocytes showed no evidence of mitosis. In contrast to capillary podocytes, the Bowman epithelial cells of diabetic rats showed increased labeling, often surrounding sclerotic capillaries. These observations suggest a critical role of Bowman's epithelial cells in the development of irreversibly sclerotic glomeruli in diabetic nephropathy.
G Osawa; T Sasaki; T Sato; M Yamada; Y Kitano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of diabetic complications     Volume:  5     ISSN:  0891-6632     ISO Abbreviation:  J Diabet Complications     Publication Date:    1991 Apr-Sep
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8708656     Medline TA:  J Diabet Complications     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-7     Citation Subset:  IM    
Department of Internal Medicine (Nephrology Section), Kawasaki Medical School, Kurashiki, Japan.
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MeSH Terms
Capillaries / pathology,  ultrastructure
Diabetes Mellitus, Experimental / pathology*,  physiopathology
Diabetic Nephropathies / pathology*,  physiopathology
Glomerular Mesangium / pathology,  ultrastructure
Kidney Glomerulus / blood supply,  pathology*,  ultrastructure
Microscopy, Electron
Rats, Inbred Strains

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