Document Detail


Kinetic studies on sex difference in susceptibility to chronic benzene intoxication--with special reference to body fat content.
MedLine Citation:
PMID:  1103957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sex difference in the susceptibility to haematopoietic disorders induced by benzene was studied kinetically with a special reference to its relation with the body fat content. In rats of both sexes with a large body fat content, benzene was eliminated more slowly and remained in the body for a longer time than in rats with a small body fat content. In accord with this finding, the decrease in white blood cell numbers during a chronic benzene exposure was observed only in the groups of rats which had a large volume of fat tissue. In an experimental human exposure, the elimination of benzene was slower in the females than in the males. The kinetic study revealed that the slower elimination in the females is due primarily to the bulky distribution of body fat tissue in that sex. From these results obtained from the experimental exposure of men and rats to benzene, it was concluded that the human female, with her massive body fat tissue, shows an inherent disposition to be susceptible to a chemical such as benzene which has a high affinity with fat tissue.
Authors:
A Sato; T Nakajima; Y Fujiwara; N Murayama
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  32     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-01     Completed Date:  1976-03-01     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Animals
Benzene / blood,  metabolism,  toxicity*
Body Composition
Body Weight
Clinical Trials as Topic
Erythrocyte Count
Female
Humans
Kinetics
Leukocyte Count
Male
Rats
Sex Factors
Chemical
Reg. No./Substance:
71-43-2/Benzene
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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