Document Detail

Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children.
MedLine Citation:
PMID:  18341089     Owner:  NLM     Status:  MEDLINE    
While acute changes in systemic pro-/antiinflammatory cytokines occur with exercise, individual kinetics during and following exercise remain unclear; particularly, information is scarce regarding children. This study investigated the exercise-induced kinetic profiles of major pro-/anti-inflammatory mediators in 21 healthy children (13.9 +/- 0.8 yr, 7 M/14 F). Exercise was 30 min of intermittent cycling at approximately 80% VO2max. Multiple blood samples were drawn at baseline, during, and following exercise for cytokines assay. IL-1alpha, IL-6, IL-17, IL-8, IP-10, MIP-1alpha, and MIP-1beta initially decreased (nadir: 14-19 min into exercise) and subsequently exceeded baseline levels (peaks: 20-24 min into exercise). TNF-alpha, IL-12p70, IL-1RA, IL-4, EGF, TGF-alpha, GM-CSF, Eotaxin, and MCP-1 were moderately and persistently decreased throughout. VEGF was unchanged; sCD40L was elevated during exercise and recovery. Our results indicate that key immunomodulators display non-linear, biphasic kinetic profiles in response to exercise, suggesting that detection of exercise-induced changes over baseline may depend on exercise duration and sampling timing.
Jaime S Rosa; Stacy R Oliver; Rebecca L Flores; Scott C Graf; Andria M Pontello; Milagros Lbardolaza; Frank P Zaldivar; Pietro R Galassetti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  20     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1293-305     Citation Subset:  IM    
Department of Pharmacology, School of Medicine, University of California, Irvine, CA, USA.
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MeSH Terms
Anti-Inflammatory Agents / blood*
CD40 Ligand / blood
Exercise / physiology*
Exercise Test / methods
Immunologic Factors / blood
Inflammation Mediators / blood*
Interleukin-1alpha / blood
Interleukin-6 / blood
Oxygen Consumption / physiology
Physical Fitness / physiology
Sexual Maturation / physiology
Time Factors
Tumor Necrosis Factor-alpha / blood
Vascular Endothelial Growth Factor A / blood
Grant Support
M01-RR00827-28/RR/NCRR NIH HHS
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunologic Factors; 0/Inflammation Mediators; 0/Interleukin-1alpha; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 0/Vascular Endothelial Growth Factor A; 147205-72-9/CD40 Ligand

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