Document Detail

Kinetic parameters of neutral amino acid transport in hybrids between malignant and non-malignant cells.
MedLine Citation:
PMID:  6746775     Owner:  NLM     Status:  MEDLINE    
The kinetics of neutral amino acid transport were examined in isogeneic matched pairs of hybrid cells, one member of each pair being tumorigenic, the other not. The L system of transport, which is sodium-independent, was measured by the uptake of leucine, and the A system, which is sodium-dependent, by the uptake of methylaminoisobutyric acid. Although there was variation from one cell type to another in both Km and Vmax for the transport of these amino acids, no systematic change was found to be associated with tumorigenicity. This is in marked contrast with hexose uptake where tumorigenicity was invariably found to be associated with a reduction in Km. It thus appears that whatever molecular change is responsible for the alteration in the kinetics of hexose transport, it is specific, at least to the extent that it does not affect either sodium-dependent or sodium-independent transport of neutral amino acids.
M K White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cell science     Volume:  67     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-09-12     Completed Date:  1984-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism*
Aminoisobutyric Acids / metabolism
Biological Transport, Active
Hybrid Cells / metabolism*
Leucine / metabolism
Neoplasms / metabolism*
Sodium / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Aminoisobutyric Acids; 2566-34-9/2-(methylamino)isobutyric acid; 61-90-5/Leucine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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