Document Detail

Kinetic determination of carbimazole, methimazole and propylthiouracil in pharmaceuticals, animal feed and animal livers.
MedLine Citation:
PMID:  7710122     Owner:  NLM     Status:  MEDLINE    
Kinetic methods are proposed for the determination of carbimazole(CBZ), methimazole(MMI) and propylthiouracil(PTU) based on their inhibitory effects on the palladium(II)-catalysed reaction between the pyronine G and hypophosphite ions. The reactions are monitored spectrophotometrically at 548 nm. The influence of reaction variables and the interfering effect of other substances were studied. Under the selected experimental conditions (CBZ: 3.6 x 10(-5) mol l-1 pyronine G; pH 3.0; 0.7 microgram ml-1 PdII and 0.2 mol l-1 H2PO2-; MMI: 6 x 10(-5) mol l-1 pyronine G, pH 3.0; 0.7 microgram ml-1 PdII, 0.4 mol l-1 H2PO2-; PTU: 3.6 x 10(-5) mol l-1 pyronine G; pH 3.0; 0.7 microgram ml-1 PdII and 0.3 mol l-1 H2PO2-), these three antithyroids were determined in the following ranges: CBZ, 0.04-0.70 microgram ml-1; MMI, 0.04-0.50 microgram ml-1; PTU 0.08-1.00 microgram ml-1. The methods were applied to the determination of CBZ, MMI and PTU, in pharmaceuticals, animal feed and animal livers.
M Soledad García; M I Albero; C Sánchez-Pedreño; L Tobal
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Analyst     Volume:  120     ISSN:  0003-2654     ISO Abbreviation:  Analyst     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-05     Completed Date:  1995-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
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MeSH Terms
Animal Feed / analysis*
Carbimazole / analysis*
Liver / chemistry*
Methimazole / analysis*
Pharmaceutical Preparations / analysis*
Propylthiouracil / analysis*
Spectrum Analysis
Reg. No./Substance:
0/Pharmaceutical Preparations; 22232-54-8/Carbimazole; 51-52-5/Propylthiouracil; 60-56-0/Methimazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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