Document Detail


Kinetic characterization of a novel cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, for myocardial perfusion imaging.
MedLine Citation:
PMID:  20669059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intense liver uptake of (99m)Tc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, in comparison with MIBI.
METHODS: Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis.
RESULTS: Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after (99m)Tc-15C5-PNP administration. (99m)Tc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that (99m)Tc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI.
CONCLUSIONS: (99m)Tc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.
Authors:
Zhonglin Liu; Liying Chen; Shuang Liu; Christy Barber; Gail D Stevenson; Lars R Furenlid; Harrison H Barrett; James M Woolfenden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-29
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  17     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-11     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  858-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Liver / metabolism
Male
Myocardial Perfusion Imaging / methods*
Myocardium / metabolism
Organotechnetium Compounds / diagnostic use*,  pharmacokinetics
Radiopharmaceuticals / diagnostic use*,  pharmacokinetics
Rats
Rats, Sprague-Dawley
Technetium Tc 99m Sestamibi / diagnostic use
Tissue Distribution
Tomography, Emission-Computed, Single-Photon / methods*
Grant Support
ID/Acronym/Agency:
P41 EB002035/EB/NIBIB NIH HHS; P41 EB002035-12/EB/NIBIB NIH HHS; P41-EB002035/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 971Z4W1S09/Technetium Tc 99m Sestamibi
Comments/Corrections
Comment In:
J Nucl Cardiol. 2010 Oct;17(5):771-4   [PMID:  20683788 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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