| Kinetic characterization of a novel cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, for myocardial perfusion imaging. | |
| | |
MedLine Citation:
|
PMID: 20669059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Intense liver uptake of (99m)Tc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, in comparison with MIBI. METHODS: Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis. RESULTS: Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after (99m)Tc-15C5-PNP administration. (99m)Tc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that (99m)Tc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI. CONCLUSIONS: (99m)Tc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake. |
| | |
Authors:
|
Zhonglin Liu; Liying Chen; Shuang Liu; Christy Barber; Gail D Stevenson; Lars R Furenlid; Harrison H Barrett; James M Woolfenden |
Related Documents
:
|
12605969 - Myocardial perfusion changes in patients irradiated for left-sided breast cancer and co... 10096509 - Preliminary evaluation of 2-[4-[3-tert-butylamino)-2-hydroxypropoxy]phenyl]-3-methyl-6-... 20693129 - Myocardial perfusion spect and dobutamine stress tissue doppler imaging in evaluation o... 8465779 - Diagnosis of right ventricular infarction by overlap images of simultaneous dual emissi... 6315629 - Comparison of 99mtc phosphate and diphosphonate complexes in experimental renal infarcts. 6779029 - Noninvasive detection of coronary artery disease by myocardial imaging with thallium-20... 9793779 - Basic fibroblast growth factor induces myocardial hypertrophy following acute infarctio... 10426859 - Clinical epidemiology of acute myocardial infarction. 10574409 - Femoral neuropathy following cardiac catheterization for balloon mitral valvotomy. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-29 |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 17 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-16 Completed Date: 2011-01-11 Revised Date: 2012-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 858-67 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Arizona, P.O. Box 245067, Tucson, AZ 85724-5067, USA. zliu@radiology.arizona.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Liver / metabolism Male Myocardial Perfusion Imaging / methods* Myocardium / metabolism Organotechnetium Compounds / diagnostic use*, pharmacokinetics Radiopharmaceuticals / diagnostic use*, pharmacokinetics Rats Rats, Sprague-Dawley Technetium Tc 99m Sestamibi / diagnostic use Tissue Distribution Tomography, Emission-Computed, Single-Photon / methods* |
| Grant Support | |
ID/Acronym/Agency:
|
P41 EB002035/EB/NIBIB NIH HHS; P41 EB002035-12/EB/NIBIB NIH HHS; P41-EB002035/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
| Comments/Corrections | |
Comment In:
|
J Nucl Cardiol. 2010 Oct;17(5):771-4
[PMID:
20683788
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The hypersensitive esophagus: pathophysiology, evaluation, and treatment options.
Next Document: Maternal mortality in Switzerland 1995-2004.