Document Detail

Kinetic changes of antibody to M. leprae and its relation with clinical disease.
MedLine Citation:
PMID:  12899385     Owner:  NLM     Status:  MEDLINE    
A sero-epidemiological survey on 1,833 healthy residents was carried out in 6 villages of a leprosy high-endemic area in Wenshan and Guangnan counties, Yunnan Province. The part of the residents with initially antibody-positive as well as the part of residents with initially antibody-negative have been followed up for 3 consecutive years by serology and clinical examination for studying kinetic changes of antibody to M. leprae and its relation with clinical disease. The results showed that the rates of subclinical infection of leprosy in a high-endemic area are different from village to village, and the risk of developing clinical disease does not associate with subclinical infection rate. It correlates with the number of cured accumulative leprosy cases and active cases within the village. The authors consider that in leprosy high-endemic villages, especially those cropped up new multi-bacillary leprosy cases frequently in recent years, it may be helpful to use serology to detect early leprosy cases.
S Jianping; L Wenzhong; Y Ganyun; W Wanhui; Y Liangbin; C Xiangsheng; H Wenbiao; L Fenwu; R Shunpeng
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  14     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  2003-08-05     Completed Date:  2003-11-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  China    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
Institute of Dermatology, CAMS & PUMC, Nanjing 210042.
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MeSH Terms
Antibodies, Bacterial / analysis*
Carrier State / immunology*
Leprosy / immunology*
Middle Aged
Mycobacterium leprae / immunology*
Seroepidemiologic Studies
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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