| Kinetic assessment of manganese using magnetic resonance imaging in the dually perfused human placenta in vitro. | |
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MedLine Citation:
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PMID: 3691434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transfer and distribution of paramagnetic manganese was investigated in the dually perfused human placenta in vitro (using 10, 20, 100 microM Mn with and without 54Mn) using magnetic resonance imaging (MRI) and conventional radiochemical techniques. The human placenta concentrated 54Mn rapidly during the first 15 min of perfusion and by 4 hr was four times greater than the concentrations of Mn in the maternal perfusate, while the concentration of Mn in the fetal perfusate was 25% of the maternal perfusate levels. Within placentae, 45% of the 54Mn was free in the 100,000g supernatant, with 45% in the 1,000g pellet. The magnetic field dependence of proton nuclear spin-lattice relaxation time (T1) in placental tissue supports this Mn binding. Mn primarily affected the MRI partial saturation rather than spin-echo images of the human placenta, which provided for the separation of perfusate contributions from those produced by Mn. The washout of the Mn from the placenta was slow compared with its uptake, as determined by MRI. Thus, Mn was concentrated by the human placenta, but transfer of Mn across the placenta was limited in either direction. These studies also illustrate the opportunity for studies of human placental function using magnetic resonance imaging as a noninvasive biomarker. |
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Authors:
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R K Miller; D R Mattison; M Panigel; T Ceckler; R Bryant; P Thomford |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Environmental health perspectives Volume: 74 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-02-17 Completed Date: 1988-02-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-91 Citation Subset: IM |
Affiliation:
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Department of Obstetrics/Gynecology, University of Rochester, School of Medicine and Dentistry, NY 14642. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Kinetics Magnetic Resonance Imaging Manganese / pharmacokinetics* Perfusion Placenta / anatomy & histology, metabolism* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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CA40699/CA/NCI NIH HHS; ES01247/ES/NIEHS NIH HHS; ES02774/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-96-5/Manganese |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 10 Year: 1987 Volume: 74First Page: 81 Last Page: 91 ID: 1474511 PubMed Id: 3691434 |
| Kinetic assessment of manganese using magnetic resonance imaging in the dually perfused human placenta in vitro. | |
| R K Miller | |
| D R Mattison | |
| M Panigel | |
| T Ceckler | |
| R Bryant | |
| P Thomford | |
| Department of Obstetrics/Gynecology, University of Rochester, School of Medicine and Dentistry, NY 14642. |
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