Document Detail

Kinetic analysis and mathematical modeling of growth and lactic acid production of Lactobacillus casei var. rhamnosus in milk whey.
MedLine Citation:
PMID:  21094727     Owner:  NLM     Status:  MEDLINE    
Lactobacillus casei is a lactic acid bacterium (LAB) that colonizes diverse ecological niches and that has found broad commercial application. The aim of this study was to characterize the kinetics of biomass production, lactic acid production, and substrate consumption of Lactobacillus casei var. rhamnosus cultured in deproteinized milk whey. Batch culture experiments were performed in an instrumented, 2-L, stirred tank bioreactor using different inoculum concentrations (0.5 to 1.0 g/L) and lactose levels (35 to 70 g/L). The time series of experimental data corresponding to biomass growth, lactose consumption, and lactic acid formation were differentiated to calculate the corresponding kinetic rates. Strong exponentially dependent product inhibition effects were evident at low lactic acid concentrations, and lactic acid production rate was partially associated with biomass growth. A mathematical model is presented that reproduces the experimental lactose, biomass, and lactic acid concentration profiles.
M M Alvarez; E J Aguirre-Ezkauriatza; A Ramírez-Medrano; A Rodríguez-Sánchez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  93     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5552-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
Centro de Biotecnologia-FEMSA, Tecnológico de Monterrey, Ave. Eugenio Garza Sada, 2501 sur Monterrey, NL, México.
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MeSH Terms
Culture Media / metabolism
Lactic Acid / biosynthesis*
Lactobacillus casei / growth & development*,  metabolism*
Lactose / analysis
Milk / chemistry,  microbiology*
Milk Proteins
Models, Biological
Reg. No./Substance:
0/Culture Media; 0/Milk Proteins; 0/whey protein; 50-21-5/Lactic Acid; 63-42-3/Lactose

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