| Kinetic analysis of D-xylose distribution after intravenous administration to mares. | |
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MedLine Citation:
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PMID: 8427459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multicompartmental analysis was applied to study the kinetics of D-xylose distribution after IV administration to healthy mares deprived of food for 12 and 96 hours. Urinary excretion of D-xylose was measured over a 15-hour period after administration. The plasma D-xylose concentrations in this study were in the range found after oral tolerance testing. The disposition of D-xylose was described by a two-compartment model with linear kinetic characteristics. Total volume of distribution decreased significantly (P < 0.025) from 0.270 L/kg of body weight after the 12-hour period of food deprivation to 0.235 L/kg after the 96-hour period. Fractional rate of transfer between the central and peripheral compartments did not change after 96 hours without food. Approximately a third of the D-xylose administered was recovered in the urine. Difference in urinary elimination between the 12- and 96-hour periods was not significant. Nonrenal elimination rate was determined to be twice the renal elimination rate. The results indicated that formal kinetic analysis can provide useful information about D-xylose distribution in horses. The decreased D-xylose space found after a 96-hour period of food deprivation would tend to increase the plasma D-xylose concentration, and this may help in the interpretation of the D-xylose absorption test applied to anorectic horses. |
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Authors:
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P L Ferrante; D E Freeman; C F Ramberg; D S Kronfeld |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: American journal of veterinary research Volume: 54 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-03-02 Completed Date: 1993-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 147-51 Citation Subset: IM |
Affiliation:
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Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square 19348. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Food Deprivation / physiology Horses / metabolism* Injections, Intravenous / veterinary Models, Biological Xylose / pharmacokinetics*, urine |
| Chemical | |
Reg. No./Substance:
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0/Xylose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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