Document Detail

Kinetic analysis of D-xylose distribution after intravenous administration to mares.
MedLine Citation:
PMID:  8427459     Owner:  NLM     Status:  MEDLINE    
Multicompartmental analysis was applied to study the kinetics of D-xylose distribution after IV administration to healthy mares deprived of food for 12 and 96 hours. Urinary excretion of D-xylose was measured over a 15-hour period after administration. The plasma D-xylose concentrations in this study were in the range found after oral tolerance testing. The disposition of D-xylose was described by a two-compartment model with linear kinetic characteristics. Total volume of distribution decreased significantly (P < 0.025) from 0.270 L/kg of body weight after the 12-hour period of food deprivation to 0.235 L/kg after the 96-hour period. Fractional rate of transfer between the central and peripheral compartments did not change after 96 hours without food. Approximately a third of the D-xylose administered was recovered in the urine. Difference in urinary elimination between the 12- and 96-hour periods was not significant. Nonrenal elimination rate was determined to be twice the renal elimination rate. The results indicated that formal kinetic analysis can provide useful information about D-xylose distribution in horses. The decreased D-xylose space found after a 96-hour period of food deprivation would tend to increase the plasma D-xylose concentration, and this may help in the interpretation of the D-xylose absorption test applied to anorectic horses.
P L Ferrante; D E Freeman; C F Ramberg; D S Kronfeld
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of veterinary research     Volume:  54     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-02     Completed Date:  1993-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square 19348.
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MeSH Terms
Food Deprivation / physiology
Horses / metabolism*
Injections, Intravenous / veterinary
Models, Biological
Xylose / pharmacokinetics*,  urine
Reg. No./Substance:

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