Document Detail


A kinetic study of accumulation and elimination of microcystin-LR in yellow perch (Perca flavescens) tissue and implications for human fish consumption.
MedLine Citation:
PMID:  22363240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are important for determining the potential for microcystins to be transferred up the food web and for predicting potential human health impacts. The main objective of this work was to conduct laboratory experiments to investigate the kinetics of toxin accumulation in fish tissue. An oral route of exposure was employed in this study, in which juvenile yellow perch (Perca flavescens) were given a single oral dose of 5 or 20 μg of microcystin-LR (MC-LR) via food and accumulation in the muscle, liver, and tank water were measured over 24 h. Peak concentrations of the water soluble fraction of microcystin were generally observed 8-10 h after dosing in the liver and after 12-16 h in the muscle, with a rapid decline in both tissues by 24 h. Up to 99% of the total recoverable (i.e., unbound) microcystin was measured in the tank water by 16 h after exposure. The relatively rapid uptake and elimination of the unbound fraction of microcystin in the liver and muscle of juvenile yellow perch within 24 h of exposure indicates that fish consumption may not be a major route of human exposure to microcystin, particularly in the Great Lakes.
Authors:
Julianne Dyble; Duane Gossiaux; Peter Landrum; Donna R Kashian; Steven Pothoven
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-12-08
Journal Detail:
Title:  Marine drugs     Volume:  9     ISSN:  1660-3397     ISO Abbreviation:  Mar Drugs     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101213729     Medline TA:  Mar Drugs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2553-71     Citation Subset:  IM    
Affiliation:
NOAA Great Lakes Environmental Research Laboratory, 4840 South State Road, Ann Arbor, MI 48108, USA. juli.dyble@noaa.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Food Contamination*
Humans
Kinetics
Liver / metabolism
Microcystins / pharmacokinetics*
Muscles / metabolism
Perches / metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Microcystins; 101043-37-2/cyanoginosin LR
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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