Document Detail


Kindling induces neuropsin mRNA in the mouse brain.
MedLine Citation:
PMID:  8864305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropsin mRNA expression was analyzed and mapped in the mouse brains after kindling epileptogenesis by using in situ hybridization histochemistry. Dynamic increases of the neuropsin mRNA were observed in the layer II of prelimbic, somatosensory, auditory, perirhinal, entorhinal, and piriform cortices in an activity-dependent manner, though no neuropsin gene was expressed in these areas in control mice. In addition to the confirmation of our previous studies showing increases of mRNA in the hippocampus and amygdaloid complex, there were also remarkable increases of the neuropsin mRNA in the limbic areas, such as the accessory olfactory nucleus, the medial and lateral septal nucleus, the nucleus of diagonal band, the substantia innominata and the zona incerta. The dynamic activity-dependent changes of the gene expression and the site-specificity of neuropsin localization are suggesting that this molecule is implicated in cortical- and limbic-specific neuronal reorganization.
Authors:
A Okabe; Y Momota; S Yoshida; A Hirata; J Ito; H Nishino; S Shiosaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  728     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-07     Completed Date:  1997-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Affiliation:
Department of Structural Cell Biology, Nara Institute of Science and Technology (NAIST), Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Brain Mapping / methods*
Cerebral Cortex / metabolism
Electric Stimulation
Epilepsy / etiology,  metabolism*
Hippocampus / metabolism
Kallikreins*
Kindling, Neurologic / physiology*
Limbic System / metabolism
Mice
Mice, Inbred Strains
RNA, Messenger / biosynthesis*
Serine Endopeptidases / genetics*,  physiology
Chemical
Reg. No./Substance:
0/RNA, Messenger; EC 3.4.21.-/KLK8 protein, human; EC 3.4.21.-/Kallikreins; EC 3.4.21.-/Serine Endopeptidases

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