Document Detail

Killing kinetics of five orally administered antibiotics at clinically achievable concentrations against Moraxella catarrhalis.
MedLine Citation:
PMID:  1486888     Owner:  NLM     Status:  MEDLINE    
Time-kill kinetic studies were used to measure the bactericidal activity of amoxicillin/clavulanic acid (in a new form for pediatric use), cefaclor, cefuroxime, cefixime and erythromycin against 30 beta-lactamase producing Moraxella catarrhalis strains. Antibiotics were tested at the mean maximum serum concentration observed after administration of a standard dose and at 0.5 x Cmax, 0.33 x Cmax and 0.25 x Cmax. A 2 log10 reduction in colony counts was obtained with the Cmax of amoxicillin/clavulanic acid and cefixime after 5 h of incubation. After 24 h of incubation a decrease of 3 and 4 log was observed with cefixime and amoxicillin/clavulanic acid respectively. At 0.5 x Cmax and 0.33 x Cmax, bactericidal activity was obtained only with amoxicillin/clavulanic acid.
E Bingen; F Bourgeois; H Chardon; C Doit; N Lambert-Zechovsky
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  11     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  923-6     Citation Subset:  IM    
Service de Microbiologie, Hôpital Robert Debré, Paris, France.
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MeSH Terms
Amoxicillin / pharmacology
Amoxicillin-Potassium Clavulanate Combination
Anti-Bacterial Agents / pharmacology*
Cefaclor / pharmacology
Cefotaxime / analogs & derivatives,  pharmacology
Cefuroxime / pharmacology
Clavulanic Acid
Clavulanic Acids / pharmacology
Colony Count, Microbial
Drug Combinations
Drug Therapy, Combination / pharmacology
Erythromycin / pharmacology
Microbial Sensitivity Tests / methods*
Moraxella (Branhamella) catarrhalis / drug effects*,  enzymology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Clavulanic Acids; 0/Drug Combinations; 114-07-8/Erythromycin; 26787-78-0/Amoxicillin; 53994-73-3/Cefaclor; 55268-75-2/Cefuroxime; 58001-44-8/Clavulanic Acid; 63527-52-6/Cefotaxime; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination; 79350-37-1/Cefixime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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