Document Detail


Killing effects of 5-fluorouracil on human biliary tract cancer cell lines.
MedLine Citation:
PMID:  9917499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Data concerning the cellular sensitivity of human biliary tract cancer cell lines to 5-FU are scarce. The purpose of the present study was to evaluate the cellular sensitivity of Mz-ChA-2 (derived from gall bladder cancer) and SK-ChA-1 (derived from bile duct cancer) to 5-FU. The clonogenic capacity of these lines after pulse (1 h) or continuous (168 h) administration of various 5-FU concentrations (0.1-100 microg/ml) was evaluated in exponentially growing cells as well as in those that had reached the plateau phase. In both cell lines, exponentially growing cells were 1.8-times more susceptible to 5-FU than those in plateau phase. However, when cells in the same growth phase were compared, Mz-ChA-2 cells were 10 times more sensitive to the drug than SK-ChA-1 cells. Regardless of the growth phase or cell line, increasing the duration of exposure to 5-FU decreased the proportion of surviving cells. Even at a non-cytocidal dosage, exposing the cells for three doubling times markedly decreased the number of viable cells remaining after treatment.
Authors:
Y Moon; T Todoroki; T Ohno; K Fukao; J B Little
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oncology     Volume:  14     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
Affiliation:
Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Antimetabolites, Antineoplastic / pharmacology*,  therapeutic use
Biliary Tract Neoplasms / drug therapy*,  pathology
Cell Death / drug effects
Cell Division / drug effects
Dose-Response Relationship, Drug
Fluorouracil / pharmacology*,  therapeutic use
Humans
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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