Document Detail

Kikuchi-Fujimoto disease manifesting as recurrent thrombocytopenia and Mobitz type II atrioventricular block in a 7-year-old girl: a case report and analysis of 138 Chinese childhood Kikuchi-Fujimoto cases with 10 years of follow-up in 97 patients.
MedLine Citation:
PMID:  17931395     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The diagnosis of Kikuchi-Fujimoto disease (KFD) is challenging for a paediatrician. Recognizing unusual clinical presentations and features of KFD is essential for doctors to obtain a thorough understanding of this clinical entity. METHOD: We reported a case recently diagnosed in our ward with manifestation of recurrent thrombocytopenia and Mobitz type II atrioventricular block, which is very unusual in childhood KFD. We also used three powerful Chinese Journal Search Engines (, and ScienceChina) to search the cases reported in China from 1989 to 2006. RESULTS: One hundred seventy-three patients younger than 16 years old with pathologic proof of KFD were identified. Among them, 138 cases with detailed clinical records from eight different provinces and cities were analyzed, and of which 97 patients were followed-up for average of 10 years and the outcomes are discussed. CONCLUSIONS: KFD is characterized by a spectrum of distinctive features, but also a variety of systemic manifestations. A hyperimmune reaction to unidentified agents as well as an autoimmune component may play an important role in this disease. Early corticosteroid therapy may improve the long-term prognosis of KFD in children.
Fu Jun-Fen; Wang Chun-Lin; Liang Li; Colin Dayan; Dong Guan-Ping; Hong Fang
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-10-11
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1844-7     Citation Subset:  IM    
Department of Endocrinology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
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MeSH Terms
Atrioventricular Block / diagnosis,  etiology
Child, Preschool
Glucocorticoids / therapeutic use
Histiocytic Necrotizing Lymphadenitis / complications,  diagnosis*,  drug therapy
Lymph Nodes / pathology*
Thrombocytopenia / etiology
Reg. No./Substance:

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