| Kikuchi-Fujimoto Disease: PET/CT Assessment of a Rare Cause of Cervical Lymphadenopathy. | |
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MedLine Citation:
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PMID: 21716016 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : Kikuchi-Fujimoto disease (KFD), formerly called subacute necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. The purpose of this study was to evaluate the usefulness of FDG PET/CT for distinguishing KFD from non-Hodgkin lymphoma (NHL). MATERIALS AND METHODS: : Twenty-two patients with cervical lymphadenopathy (8 with KFD and 14 with NHL) underwent CT and FDG PET/CT scans to examine the cervical lymphadenopathy. Regional values of FDG uptake were evaluated using the standardized uptake value (SUV) and partial volume corrected SUV (corSUV) based on the count recovery coefficient. Tumor size (mm), SUV, and corSUV were compared among KFD, indolent NHL, and aggressive NHL. RESULTS: : KFD lesions tended to be smaller (13.8 ± 5.4 mm) than those of indolent (25.4 ± 11.8) and aggressive (29.7 ± 18.8) NHL, whereas there were no significant differences in size. As for SUV, a significant difference was observed only between indolent and aggressive (6.4 ± 1.5 and 17.3 ± 9.3, P < 0.05) NHL; however, KFD showed a significantly greater corSUV (23.8 ± 10.6) as compared with indolent NHL (9.2 ± 5.1, P < 0.05), which did not show a significant difference from aggressive NHL (21.4 ± 10.2). FDG PET/CT detected thoracoabdominal lesions in 2 patients (25%) with KFD. CONCLUSIONS: : KFD shows high FDG uptake for size, which may reflect the pathologic characteristics, including necrotizing lymphocytes and numerous histiocytes (macrophages) surrounding small necrotic foci. FDG PET/CT will be useful for detecting noncervical lesions of KFD and distinguishing KFD from NHLs using both SUV and corSUV. |
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Authors:
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Tetsuya Tsujikawa; Tatsuro Tsuchida; Yoshiaki Imamura; Masato Kobayashi; Satoko Asahi; Kazuhiro Shimizu; Kazunobu Tsuji; Hidehiko Okazawa; Hirohiko Kimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 661-4 Citation Subset: IM |
Affiliation:
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From the *Department of Radiology, University of Fukui, Fukui, Japan; †Division of Surgical Pathology, University of Fukui, Fukui, Japan; ‡School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; and §Biomedical Imaging Research Center, University of Fukui, Fukui, Japan. |
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