| Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study. | |
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MedLine Citation:
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PMID: 18057869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown. METHODS: One hundred and seventy unrelated Caucasians with T2DM underwent multidetector-row computed tomography of the neck, chest, and abdomen to measure calcified plaque in the coronary artery (CorCP), carotid artery (CarCP), and infrarenal aorta (AorCP). Spearman's rank correlation coefficients were used to assess associations between TKV and subclinical renal and cardiovascular disease. Partial correlation coefficients were computed to adjust for the potential confounding effects of age, sex, body mass index, glomerular filtration rate (GFR), diabetes duration, and hemoglobin A(1c). Values are expressed as mean +/- SD (median in parentheses). RESULTS: The study group (51% female) had a mean age of 62.9 +/- 8.5 (62.3) years, a T2DM duration of 11.5 +/- 6.8 (10.0) years, a urinary albumin:creatinine ratio of 109.9 +/- 396 (17.6) mg/g, a GFR of 63.8 +/- 12.8 (63.2) ml/min, a TKV of 272.4 +/- 69.7 (261.9) cm(3), CorCP 2,170 +/- 3,394 (653), CarCP 374 +/- 673 (104), AorCP 14,569 +/- 17,480 (8,370), and a carotid artery intima-media thickness of 0.70 +/- 0.14 (0.68) mm. Adjusting for age, sex, body mass index, diabetes duration, GFR, and hemoglobin A(1c), the TKV was significantly associated with AorCP (r = 0.20, p = 0.016), but not with CorCP, CarCP, or carotid artery intima-media thickness (all p >or= 0.25). No significant associations were detected between TKV and blood pressure or albuminuria. CONCLUSIONS: In Caucasians with T2DM, TKV and calcified atherosclerotic plaque in the infrarenal abdominal aorta are positively associated. Common mechanisms linking renal matrix deposition with aortic atherosclerosis may underlie this association and require further study. |
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Authors:
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Anita M Saran; Fang-Chi Hsu; Kurt K Lohman; J Jeffrey Carr; Donald W Bowden; Lynne E Wagenknecht; Barry I Freedman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-12-05 |
Journal Detail:
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Title: American journal of nephrology Volume: 28 ISSN: 1421-9670 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-06-23 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: IM |
Copyright Information:
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(c) 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine/Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1053, USA. asaran@wfubmc.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albuminuria / pathology* Aorta, Abdominal / pathology, radiography Atherosclerosis / pathology, radiography* Blood Pressure / physiology* Diabetes Mellitus, Type 2 / complications, diagnosis*, physiopathology Diabetic Angiopathies / pathology, radiography Diabetic Neuropathies / pathology, radiography Female Humans Kidney / pathology, physiopathology, radiography* Male Middle Aged Organ Size Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR007122-130204/RR/NCRR NIH HHS; M01 RR007122-140204/RR/NCRR NIH HHS; M01 RR007122-150204/RR/NCRR NIH HHS; MO1 RR07122/RR/NCRR NIH HHS; R01 AR048797-01/AR/NIAMS NIH HHS; R01 AR048797-02/AR/NIAMS NIH HHS; R01 AR048797-03/AR/NIAMS NIH HHS; R01 AR048797-04/AR/NIAMS NIH HHS; R01 AR48797/AR/NIAMS NIH HHS; R01 HL67348/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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