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Kidney transplantation using donors over 70 years old: are the criteria for organ allocation too expanded?
MedLine Citation:
PMID:  23026576     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The scarcity of organs available for transplantation has led to the use of kidneys from old deceased donors including those ≥70 years of age. The results of kidney transplants performed using such "limit" organs warrent further study.
METHODS: We retrospectively evaluated all cadaveric heart-beating renal transplants performed from September 1996 to June 2010 using expanded-criteria donors: Group 1 included 302 transplants performed with kidneys from expanded-criteria donors aged 50-69 years; group 2 included 60 recipients of kidneys from donors aged ≥70 years. All patients were prescribed an immunossupressive regimen based on mycophenolate mofetil or mycophenolic acid, a calcineurin inhibitor, and corticosteroids, with or without monoclonal/polyclonal antibodies.
RESULTS: The baseline recipient characteristics were similar except for age, which was higher in group 2; history of previous transplantation was absent in group 2, and there was more use of induction with monoclonal or polyclonal antibodies in group 2 (65% vs 49%; P = .02). There was no significant difference in the rate of nonfunctioning grafts, delayed graft function, or acute rejection episodes in the first 6 months. There was no significant difference between groups regarding graft or patient survival.
CONCLUSIONS: The use of kidneys from donors aged ≥70 older than or years yielded generally satisfactory results.
Authors:
S Machado; N Figueiredo; M Neves; F Macário; R Alves; A Mota; M Campos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  44     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2289-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Nephrology, Renal Transplantation Unit, Hospitais da Universidade de Coimbra, Coimbra, Portugal. Electronic address: susana_machado_@hotmail.com.
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