Document Detail


[Kidney transplantation: consecutive one thousand transplants at National Institute of Medical Sciences and Nutrition Salvador Zubirán in Mexico City].
MedLine Citation:
PMID:  22916604     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
INTRODUCTION: The National Institute of Medical Sciences and Nutrition Salvador Zubiran (INCMNSZ) is a specialty hospital for adults and a teaching hospital, which performed the first kidney transplant in 1967; in 1971 it began the formal program of renal transplantation. Recently, it was performed the kidney transplant number 1000, so this article presents the information of these thousand kidney transplants, with special emphasis on survival.
MATERIAL AND METHODS: Retrospective cohort study which included 1000 consecutive transplants performed at the INCMNSZ between 1967 and June 2011. It describes the general characteristics of kidney transplant recipients, transplant-related variables, initial immunosuppression and complications. Descriptive statistics were used. The survival analysis was performed using the Kaplan-Meier method. It shows the patient survival, graft survival censored for death with functional graft and total graft survival (uncensored).
RESULTS: Patient survival at 1, 3, 5, 10, 15, and 20 years was 94.9, 89.6, 86.8, 76.9, 66.1, and 62.2%, respectively. Graft survival censored for death with functional graft at 1, 3, 5, 10, 15, and 20 years was 93.1, 87.1, 83.5, 73.9, 62.7, and 52.5% respectively. Risk factors associated with poorer graft survival were younger age of the recipient, transplant during the first period (1967-1983), and a HLA mismatch.
CONCLUSION: Patient and graft survival have improved over time through the use of better immunosuppression and use of induction therapy. Identification of risk factors affecting graft survival, allows each center to set their strategies to improve the patient's outcome.
Authors:
Lluvia Aurora Marino-Vazquez; Regina Sánchez-Ugarte; Luis Eduardo Morales-Buenrostro
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición     Volume:  63 Suppl 1     ISSN:  0034-8376     ISO Abbreviation:  Rev. Invest. Clin.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421552     Medline TA:  Rev Invest Clin     Country:  Mexico    
Other Details:
Languages:  spa     Pagination:  6-13     Citation Subset:  IM    
Affiliation:
Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, DF México.
Vernacular Title:
Trasplante renal: primeros mil trasplantes en el Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, en la Ciudad de México.
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