Document Detail


Kidney stone disease.
MedLine Citation:
PMID:  16200192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
About 5% of American women and 12% of men will develop a kidney stone at some time in their life, and prevalence has been rising in both sexes. Approximately 80% of stones are composed of calcium oxalate (CaOx) and calcium phosphate (CaP); 10% of struvite (magnesium ammonium phosphate produced during infection with bacteria that possess the enzyme urease), 9% of uric acid (UA); and the remaining 1% are composed of cystine or ammonium acid urate or are diagnosed as drug-related stones. Stones ultimately arise because of an unwanted phase change of these substances from liquid to solid state. Here we focus on the mechanisms of pathogenesis involved in CaOx, CaP, UA, and cystine stone formation, including recent developments in our understanding of related changes in human kidney tissue and of underlying genetic causes, in addition to current therapeutics.
Authors:
Fredric L Coe; Andrew Evan; Elaine Worcester
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  115     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-12-12     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2598-608     Citation Subset:  AIM; IM    
Affiliation:
Renal Section, University of Chicago, Chicago, Illinois 60637, USA. f-coe@uchicago.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Oxalate / metabolism
Calcium Phosphates / metabolism
Female
Humans
Kidney Calculi* / genetics,  metabolism,  therapy,  ultrastructure
Magnesium Compounds / metabolism
Male
Pharmaceutical Preparations / adverse effects,  metabolism
Phosphates / metabolism
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 0/Magnesium Compounds; 0/Pharmaceutical Preparations; 0/Phosphates; 15490-91-2/struvite; 25454-23-3/Calcium Oxalate; 97Z1WI3NDX/calcium phosphate
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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