| Kidney and liver contributions to salicylate metabolism in rats. | |
| | |
MedLine Citation:
|
PMID: 7957447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into urine. The comparison of a relative proportion of metabolites eliminated in whole rats with that of the isolated perfused rat liver and the perfused rat kidney showed that both kidney and liver contributed to the salicylate metabolism. The glycine conjugate of salicylate was formed predominantly in the kidney whereas both kidney and liver participated in the formation of glucuronic acid derivatives. |
| | |
Authors:
|
M Láznícek; A Láznícková |
Related Documents
:
|
18276837 - Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(lys82)beta-(lys8... 15766277 - Targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells. 3908627 - Effects of insulin, amino acids and fasting on myofibrillar protein degradation in perf... 6690477 - Selective vulnerability of the medullary thick ascending limb to anoxia in the isolated... 9089467 - Brain metabolism of progesterone, coping behaviour and emotional reactivity in male rat... 7000497 - Effects of semistarvation on skeletal homeostasis. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: European journal of drug metabolism and pharmacokinetics Volume: 19 ISSN: 0378-7966 ISO Abbreviation: Eur J Drug Metab Pharmacokinet Publication Date: 1994 Jan-Mar |
Date Detail:
|
Created Date: 1994-12-07 Completed Date: 1994-12-07 Revised Date: 2011-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 7608491 Medline TA: Eur J Drug Metab Pharmacokinet Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
|
Faculty of Pharmacy, Charles University, Hradec Králové, Czechoslovakia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biotransformation Gluconates / metabolism, urine Glycine / metabolism, urine Half-Life Kidney / metabolism* Liver / metabolism* Male Rats Rats, Wistar Salicylic Acid Salicylic Acids / pharmacokinetics*, urine Technetium Tc 99m Pentetate Tissue Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Gluconates; 0/Salicylic Acids; 56-40-6/Glycine; 65454-61-7/Technetium Tc 99m Pentetate; 69-72-7/Salicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of renal function on the pharmacokinetics of diacerein after a single oral dose.
Next Document: Pharmacokinetic study of mefloquine in Thai children aged 5-12 years suffering from uncomplicated fa...