Document Detail


Kidney and hypertension: is there a place for renalase?
MedLine Citation:
PMID:  22415317     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic kidney disease (CKD) is associated with a high risk of cardiovascular disease. It is the result of the presence of "traditional" and "nontraditional" risk factors. Hypertension occurs in approximately 80-85% of patients with CKD. The etiology of high blood pressure is multifactorial in this population. Sympathetic nervous system activity is enhanced in patients witch chronic kidney disease and correlates with increased vascular resistance and systemic blood pressure. It is the result of overspill and reduced catecholamine clearance. Recently, a new protein, named renalase (RNLS) was discovered. In experimental in vitro study it was found that RNLS degraded catecholamines and in that way it might have a significant hemodynamic effect in vivo, like decrease in cardiac contractility, heart rate and blood pressure. Some studies perforemed in patients demonstrated a lower serum renalase in CKD and haemodialysis patients comparing to healthy individuals, while some studies revealed the increased serum RNLS in dialyzed population and kidney transplant recipients. There are no data concerning the connection between renalase gen expression and activity/concentration and function of renalase. Thus, it has to be proved that renalase is not an innocent bystander, but a pathogenetic factor for hypertension. 
Authors:
Edyta Zbroch; Jolanta Małyszko; Jacek Małyszko; Marcin J Zórawski; Michał Myśliwiec
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-8
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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