| Kidney and heart interactions during cardiorenal syndrome: a molecular and clinical pathogenic framework. | |
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MedLine Citation:
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PMID: 21797745 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The heart and kidney are physiologically interconnected. Cardiorenal syndrome (CRS) is a pathological disorder where acute or chronic dysfunction in one organ may induce dysfunction in the other one. Although classical studies have proposed a role for hypertension, dyslipidemia and endothelial dysfunction, CRS should be considered as a complex molecular interplay of neurohumoral pathway activation including the sympathetic nervous system, the renin angiotensin aldosterone axis, the endothelin system and the arginine vasopressin system. This activation may induce vascular inflammation, oxidative stress, accelerated atherosclerosis, cardiac hypertrophy and both myocardial and intrarenal fibrosis with progression of CRS treatment. More recently, epigenetics has opened new pathogenic molecular routes for CRS. This will lead to a more rapid development of novel, safe and effective clinical therapies. |
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Authors:
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Claudio Napoli; Amelia Casamassimi; Valeria Crudele; Teresa Infante; Ciro Abbondanza |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Future cardiology Volume: 7 ISSN: 1744-8298 ISO Abbreviation: Future Cardiol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101239345 Medline TA: Future Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 485-97 Citation Subset: IM |
Affiliation:
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Dipartimento di Patologia Generale, Centro di Eccellenza sulle Malattie Cardiovascolari, Facoltà di Medicina e Chirurgia, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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