Document Detail

Kidney growth in children with congenital hypothyroidism.
MedLine Citation:
PMID:  18815815     Owner:  NLM     Status:  MEDLINE    
The effect of hypothyroidism on kidney size has not been studied in children. The aim of this study was to examine the role of congenital hypothyroidism and levothyroxine (L-thyroxine) treatment on renal growth. Forty children with congenital hypothyroidism and 37 healthy controls were prospectively included. The mean age of patients was 8.2+/-4.7 years. Patients had lower height and weight standard deviation scores compared with controls. The mean L-thyroxine initial age and treatment duration were 37.0 and 60.5 months, respectively. In 62.5% of patients, L-thyroxine was initiated after 6 months of age, and 60.0% of patients had severe hypothyroidism. Patients had lower kidney length and total kidney volume compared with controls (P < 0.05). No significant differences were found in kidney volume/body weight and kidney volume/ body height ratios between patients and controls (P > 0.05). Multiple regression analysis showed significant relationship between relative kidney volume and average free thyroxine level (P < 0.05). No significant differences in kidney sizes were found between patients who had L-thyroxine initiated before and after 6 months of age or between mild/moderate and severe hypothyroidism at diagnosis (P > 0.05). In conclusion, normal renal growth can be accomplished with L-thyroxine replacement despite considerable delay in treatment initiation and/or severe hypothyroidism.
Mehmet Bülbül; Semra Cetinkaya; Seçil Ekşioğlu; Serdar Ozkasap; Tayfur Giniş
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2008-09-25
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  24     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  333-40     Citation Subset:  IM    
Department of Pediatric Nephrology, Sami Ulus Children's Hospital, Ankara, Turkey.
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MeSH Terms
Child, Preschool
Congenital Hypothyroidism / drug therapy*,  physiopathology*,  ultrasonography
Insulin-Like Growth Factor Binding Proteins / blood
Insulin-Like Growth Factor I / metabolism
Kidney / anatomy & histology,  growth & development*,  ultrasonography
Organ Size
Prospective Studies
Regression Analysis
Thyroid Hormones / blood
Thyroxine / administration & dosage*
Reg. No./Substance:
0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 0/Thyroid Hormones; 67763-96-6/Insulin-Like Growth Factor I; 7488-70-2/Thyroxine

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