| Kidney growth in children with congenital hypothyroidism. | |
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MedLine Citation:
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PMID: 18815815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of hypothyroidism on kidney size has not been studied in children. The aim of this study was to examine the role of congenital hypothyroidism and levothyroxine (L-thyroxine) treatment on renal growth. Forty children with congenital hypothyroidism and 37 healthy controls were prospectively included. The mean age of patients was 8.2+/-4.7 years. Patients had lower height and weight standard deviation scores compared with controls. The mean L-thyroxine initial age and treatment duration were 37.0 and 60.5 months, respectively. In 62.5% of patients, L-thyroxine was initiated after 6 months of age, and 60.0% of patients had severe hypothyroidism. Patients had lower kidney length and total kidney volume compared with controls (P < 0.05). No significant differences were found in kidney volume/body weight and kidney volume/ body height ratios between patients and controls (P > 0.05). Multiple regression analysis showed significant relationship between relative kidney volume and average free thyroxine level (P < 0.05). No significant differences in kidney sizes were found between patients who had L-thyroxine initiated before and after 6 months of age or between mild/moderate and severe hypothyroidism at diagnosis (P > 0.05). In conclusion, normal renal growth can be accomplished with L-thyroxine replacement despite considerable delay in treatment initiation and/or severe hypothyroidism. |
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Authors:
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Mehmet Bülbül; Semra Cetinkaya; Seçil Ekşioğlu; Serdar Ozkasap; Tayfur Giniş |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2008-09-25 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 24 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 333-40 Citation Subset: IM |
Affiliation:
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Department of Pediatric Nephrology, Sami Ulus Children's Hospital, Ankara, Turkey. mbbjkank@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Congenital Hypothyroidism / drug therapy*, physiopathology*, ultrasonography Female Humans Insulin-Like Growth Factor Binding Proteins / blood Insulin-Like Growth Factor I / metabolism Kidney / anatomy & histology, growth & development*, ultrasonography Male Organ Size Prospective Studies Regression Analysis Thyroid Hormones / blood Thyroxine / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 0/Thyroid Hormones; 67763-96-6/Insulin-Like Growth Factor I; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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