| Kidney function in the very elderly with hypertension: data from the hypertension in the very elderly (HYVET) trial. | |
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MedLine Citation:
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PMID: 22910302 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: numerous reports have linked impaired kidney function to a higher risk of cardiovascular events and mortality. There are relatively few data relating to kidney function in the very elderly. METHODS: the Hypertension in the Very Elderly Trial (HYVET) was a randomised placebo-controlled trial of indapamide slow release 1.5mg ± perindopril 2-4 mg in those aged ≥80 years with sitting systolic blood pressures of ≥160 mmHg and diastolic pressures of <110 mmHg. Kidney function was a secondary outcome. RESULTS: HYVET recruited 3,845 participants. The mean baseline estimated glomerular filtration rate (eGFR) was 61.7 ml/min/1.73 m(2). When categories of the eGFR were examined, there was a possible U-shaped relationship between eGFR, total mortality, cardiovascular mortality and events. The nadir of the U was the eGFR category ≥60 and <75 ml/min/1.73 m(2). Using this as a comparator, the U shape was clearest for cardiovascular mortality with the eGFR <45 ml/min/1.73 m(2) and ≥75 ml/min/1.73 m(2) showing hazard ratios of 1.88 (95% CI: 1.2-2.96) and 1.36 (0.94-1.98) by comparison. Proteinuria at baseline was also associated with an increased risk of later heart failure events and mortality. CONCLUSIONS: although these results should be interpreted with caution, it may be that in very elderly individuals with hypertension both low and high eGFR indicate increased risk. |
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Authors:
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Ruth Peters; Nigel Beckett; Ruth Poulter; Lisa Burch; Krzysztof Narkiewicz; Robert Fagard; Dorothea Nitsch; Nan Wang; Mengying Li; Astrid Fletcher; Christopher Bulpitt |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-21 |
Journal Detail:
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Title: Age and ageing Volume: - ISSN: 1468-2834 ISO Abbreviation: Age Ageing Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375655 Medline TA: Age Ageing Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Imperial College London, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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