| Kidney function in metabolic syndrome may be improved with Pycnogenol®. | |
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MedLine Citation:
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PMID: 20657531 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: We investigated benefits of Pycnogenol(R) as an adjunct to hypotensive medication in metabolic syndrome patients with micro-albuminurea. METHODS: Fifty eight patients were treated with Ramipril and a subgroup received Pycnogenol in addition for six months. Colour Doppler duplex ultrasound was employed for cortical flow measurements. RESULTS: Blood pressure decreased with Ramipril from 188.8/95.2 to 128.2/90.2, with additional Pycnogenol from 189.3/97.2 to 122.2/85.3 (P<0.05). Kidney function improved in both groups, with 24 hour urinary albumin decreasing from 88.8 to 68.9 mg with Ramipril and from 89.3 to 42.2 mg with additional Pycnogenol (P<0.05). In both groups treatment lowered serum creatinine, with combination treatment being significantly more effective. Cortical flow velocities significantly increased with Ramipril from systolic 17.2 +/- 3.1 to 23.8 +/- 2.0 cms-1 and diastolic 4.2+/-2.8 to 2.0+/-3.1 cms-1. The addition of Pycnogenol was more effective, improving cortical flow from systolic 18.2+/-2.2 to 27.2+/-2.9 cms-1 and diastolic 4.1+/-2.2 to 9.8+/-2.1 cms-1 (P>0.05). C-reactive protein (CRP) levels decreased marginally with Ramipril, but significantly with Pycnogenol from 2.17 to 1.62 mg/dL. Pycnogenol significantly lowered fasting blood glucose to 102.3 +/- 11.2 mg/mL and HbA1c to 6.9 +/- 0.3 %. The Pycnogenol group showed a significantly lowered BMI, from baseline 26.5+/-0.9 to 25.0+/-1.2 kgm-2, without reaching statistical significance versus control. Only a limited improvement of blood lipid profile was found in both groups. CONCLUSION: Pycnogenol should be further investigated for kidney function. |
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Authors:
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S Stuard; G Belcaro; M R Cesarone; A Ricci; M Dugall; U Cornelli; G Gizzi; L Pellegrini; P J Rohdewald |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Panminerva medica Volume: 52 ISSN: 1827-1898 ISO Abbreviation: Panminerva Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421110 Medline TA: Panminerva Med Country: Italy |
Other Details:
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Languages: eng Pagination: 27-32 Citation Subset: IM |
Affiliation:
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Nephrology Unit, L'Aquila Hospital, L'Aquila, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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