Document Detail


Kidney disease mortality and environmental exposure to mercury.
MedLine Citation:
PMID:  17068093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Runcorn, North West England, has been a site of industrial activity for over 100 years. Preliminary investigations have revealed excess risk of renal mortality in the population living closest to several sources of pollution. Exposure to airborne mercury has been highlighted as a possible cause, although there is also concomitant exposure to solvents and other heavy metals in this population. The authors used validated air dispersion modeling to identify mercury-exposed populations. Standardized mortality ratios for kidney disease were computed using the North West government region as the reference. There was a significant exposure-response relation between modeled estimates of mercury exposure and risk of kidney disease mortality (test for trend: p = 0.02 for men and p = 0.03 for women), and this relation was more pronounced for estimated historical exposure (test for trend: p = 0.01 for men and p < 0.001 for women). These findings suggest that exposure to mercury is a possible cause of the excess kidney disease mortality in this population, indicating that there might still be a health legacy of the historically high levels of industrial activity in the Runcorn area.
Authors:
Susan Hodgson; Mark J Nieuwenhuijsen; Paul Elliott; Lars Jarup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-26
Journal Detail:
Title:  American journal of epidemiology     Volume:  165     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
Affiliation:
Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom. susan.hodgson@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Air Movements
Air Pollutants / analysis,  toxicity*
Chemical Industry*
England / epidemiology
Environmental Exposure / adverse effects*,  analysis
Environmental Monitoring
Female
Humans
Kidney / drug effects*
Kidney Diseases / epidemiology,  etiology,  mortality*
Male
Mercury / analysis,  toxicity*
Mercury Poisoning / complications,  epidemiology*
Middle Aged
Poverty Areas
Risk Assessment
Risk Factors
Chemical
Reg. No./Substance:
0/Air Pollutants; 7439-97-6/Mercury

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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