Document Detail

Kidney volume and albuminuria as markers of birth weight-blood pressure relationship in essential hypertension.
MedLine Citation:
PMID:  19940511     Owner:  NLM     Status:  MEDLINE    
Our aim was to analyze whether birth weight contributes to future hypertension through reduced kidney volume, and whether albuminuria could be a marker of this pathway. We included 103 patients with newly diagnosed essential hypertension and 92 normotensive controls. Blood pressure (BP) was measured using a mercury sphygmomanometer and a ABP monitor. Kidney volume was determined by ultrasound. Data on birth weight were obtained from mothers. Albuminuria was determined in 24-hour urine samples. Hypertensive patients had lower birth weight and higher albuminuria than normotensives. There was no difference in kidney volume between the two groups. We found a negative correlation between birth weight and systolic BP in the hypertensive group. BP was significantly correlated with BMI and albuminuria in the hypertensive group. Multiple regression analysis had shown the greatest impact of BMI on BP and had also demonstrated that 24-hour systolic BP showed the greatest risk for developing albuminuria in hypertensive patients. In conclusion, birth weight influences BP values in adult age, but it is not mediated by a reduced kidney volume. A strong correlation, independent of birth weight, was observed between albuminuria and BP values. Increased BMI is the most important independent risk factor responsible for BP increase, even in an early phase of essential hypertension.
Mario Laganovi?; Dusko Kuzmani?; Tajana Zeljkovi?-Vrki?; Ivan Pe?in; Zivka Dika; Bojan Jelakovi?
Publication Detail:
Type:  Journal Article     Date:  2009-11-20
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  32     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  399-404     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department for Nephrology and Arterial Hypertension, University Hospital Center Zagreb, Zagreb, Croatia.
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MeSH Terms
Albuminuria / pathology*
Biological Markers
Birth Weight / physiology*
Blood Pressure / physiology*
Body Mass Index
Hypertension / pathology*,  urine*
Kidney / pathology*
Middle Aged
Nephrons / pathology
Regression Analysis
Risk Factors
Sex Characteristics
Smoking / epidemiology
Reg. No./Substance:
0/Biological Markers

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