| Kidney Injury Molecule-1 as a Promising Biomarker for Acute Kidney Injury in Premature Babies. | |
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MedLine Citation:
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PMID: 22875659 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective To evaluate the role of urinary kidney injury molecule-1 (uKIM-1) in early determination of renal injury in premature infants with respiratory distress syndrome (RDS).Study Design Forty-eight premature babies hospitalized in the neonatal intensive care unit were included in the study and divided into three groups: group I, healthy premature infants; group II, preterm infants with RDS without acute kidney injury (AKI); group III, preterm infants with RDS and AKI. uKIM-1 and creatinine along with serum creatinine levels were measured with enzyme-linked immunosorbent assay on days 1, 3, and 7 of life.Results On day 1, uKIM-1 levels in babies with RDS and AKI were higher than the other two groups. In this group, a significant increase in uKIM-1 levels were detected on day 3 (p = 0.015). The sensitivity and specificity of uKIM-1 were calculated as 73.3% and 76.9%, respectively, along with the increase of 0.5 ng per milligram of creatinine of uKIM-1 in day 3, when compared with values on day 1. Elevated uKIM-1 on day 7 was found to increase the risk of death by 7.3 times.Conclusion Serial uKIM-1 measurements can be used as a noninvasive indicator of kidney injury and uKIM-1 can be an ideal biomarker in premature infants. |
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Authors:
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Gurkan Genc; Ozan Ozkaya; Bahattin Avci; Canan Aygun; Sukru Kucukoduk |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-8 |
Journal Detail:
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Title: American journal of perinatology Volume: - ISSN: 1098-8785 ISO Abbreviation: Am J Perinatol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Affiliation:
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Department of Pediatric Nephrology, Ondokuz Mayis University Faculty of Medicine, Children's Hospital, Samsun, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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