| Ki67 expression in different epithelial types in columnar lined oesophagus indicates varying levels of expanded and aberrant proliferative patterns. | |
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MedLine Citation:
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PMID: 16045773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate proliferative patterns in metaplastic columnar epithelia of the oesophagus, classified as oxynto-cardiac (n = 43), cardiac (n = 45) intestinal without dysplasia (n = 41), dysplastic intestinal epithelium (n = 25), and adenocarcinoma (n = 15) by Ki67 immunohistochemistry. METHODS AND RESULTS: Abnormal patterns of Ki67 immunoreactivity were classified into (i) expanded proliferation, characterized by increased levels of Ki67 expression in the deep and mid third of the foveolar pit; and (ii) aberrant proliferation, characterized by positive staining in the surface epithelium and superficial third of the foveolar pit. A significant step-wise increase in the frequency of expanded proliferation was seen in oxynto-cardiac, cardiac, intestinal and dysplastic intestinal epithelium indicative of increasing levels of damage. Aberrant proliferation was absent in oxynto-cardiac mucosa, present at a low and similar level in cardiac, intestinal and low-grade dysplastic epithelia and at a significantly increased frequency in high-grade dysplasia. CONCLUSIONS: These findings suggest that oxynto-cardiac mucosa occurs in a low damage environment and intestinal metaplasia in a high damage environment along the length of the columnar lined oesophageal segment. Aberrant proliferative patterns with Ki67 staining are not useful in differentiating reactive epithelia from low-grade dysplasia, but may prove useful in the diagnosis of high-grade dysplasia. |
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Authors:
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M Olvera; K Wickramasinghe; R Brynes; X Bu; Y Ma; P Chandrasoma |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Histopathology Volume: 47 ISSN: 0309-0167 ISO Abbreviation: Histopathology Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-27 Completed Date: 2005-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 132-40 Citation Subset: IM |
Affiliation:
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Department of Pathology, Los Angeles County/University of Southern California Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism,
pathology Barrett Esophagus / metabolism, pathology Cell Proliferation Diagnosis, Differential Epithelium / chemistry, pathology Esophageal Neoplasms / metabolism, pathology Esophagus / chemistry, pathology* Humans Immunohistochemistry Ki-67 Antigen / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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