| The Ki-67 labeling index is not a useful predictor for the follow-up of cervical intraepithelial neoplasia 1. | |
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MedLine Citation:
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PMID: 15874879 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our aim was to determine whether the Ki-67 immunostaining pattern, present on diagnosis of cervical intraepithelial neoplasia (CIN), predicts the change from low-grade to high-grade CIN over a 2-year period after diagnosis. MATERIALS AND METHODS: Of 59 cervical biopsy samples from 59 patients diagnosed as having cervical CIN, 35 were diagnosed as CIN 1 and 24 were diagnosed as CIN 2 or CIN 3. The Ki-67 immunostain showed immunopositive cells in the upper two thirds of the epithelium in all specimens. Two hundred nuclei were counted in 25 high-power fields in each specimen, including all of the epithelial layers, to determine the mean number of Ki-67-positive cells. In situ hybridization was used to demonstrate and type human papillomavirus. The chi test, Fisher exact test, Student t test, one-way analysis of variance, and Tukey test were used for statistical analysis, with significance set at p < .05. RESULTS: The mean Ki-67 labeling index for CIN 1, CIN 2, CIN 3, and CIN 2,3 were, respectively, 32.5%, 43.2%, 53.2%, and 47.8%. The statistical study showed significant differences between CIN 1 versus CIN 2, CIN 1 versus CIN 3, and CIN 1 versus CIN 2,3. For CIN 1, the mean Ki-67 labeling index was 32.8% when the lesion disappeared and was 34.6% for persisting lesions. There was no statistically significant difference. CONCLUSIONS: Ki-67 labeling index did not predict persisting CIN 1. |
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Authors:
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F Alameda; P Fuste; S Boluda; L Ferrer; T Baro; L Mariñoso; G Mancebo; R Carreras; S Serrano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of lower genital tract disease Volume: 8 ISSN: 1089-2591 ISO Abbreviation: J Low Genit Tract Dis Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2005-05-05 Completed Date: 2005-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9704963 Medline TA: J Low Genit Tract Dis Country: United States |
Other Details:
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Languages: eng Pagination: 313-6 Citation Subset: - |
Affiliation:
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Department of Pathology, Hospital Del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain. 86780@imas.imim.es |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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