Document Detail


Ki-67 and bromodeoxyuridine labeling of human choroidal melanoma cells.
MedLine Citation:
PMID:  1889233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding tumor growth patterns has implications for prognosis as well as for response and susceptibility to treatment. The antibody Ki-67 was used as a marker of cycling cells and bromodeoxyuridine (BrdUrd) was used as a marker of proliferating cells to characterize the cycling and proliferative rates of cells from human choroidal melanoma. The BrdUrd labeling indices varied from 0-1.1% and the Ki-67 labeling indices ranged from 0-3.0.3%. Linear regression modeling showed good correlation defined by the equation: Ki-67 index = 0.237 + 1.63 x BrdUrd labeling index with r = 0.919. Correlations between these indices and clinical and histologic parameters were not significant.
Authors:
D S Bardenstein; D H Char; S Kaleta-Michaels; S M Kroll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current eye research     Volume:  10     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-10-15     Completed Date:  1991-10-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of California, San Francisco.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal
Bromodeoxyuridine / diagnostic use*
Choroid Neoplasms / diagnosis*
Fluorescent Antibody Technique
Humans
Ki-67 Antigen
Melanoma / diagnosis*
Nuclear Proteins / diagnostic use*
Tumor Cells, Cultured
Tumor Markers, Biological*
Grant Support
ID/Acronym/Agency:
EY0 7504/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Ki-67 Antigen; 0/Nuclear Proteins; 0/Tumor Markers, Biological; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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