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Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus.
MedLine Citation:
PMID:  22844273     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett's esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett's esophagus, esophageal adenocarcinoma, and controls. We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). Results. In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race. Patients with cancer were predominantly men. The Ki-67 index averaged 10 ± 4 % in patients with normal gastric mucosa (n = 17), 21 ± 15 % in patients with Barrett's esophagus (n = 21), and 38 ± 16 % in patients with cancer (n = 19). Ki-67 expression was significantly different between all groups (P < 0.05). There was a strong linear correlation between Ki-67 expression and the metaplasia-adenocarcinoma sequence (P < 0.01). In patients with cancer, Ki-67 was not associated with clinical or surgical staging. Conclusions. Ki-67 antigen has increased expression along the metaplasia-adenocarcinoma sequence. There is a strong linear correlation between Ki-67 proliferative activity and Barrett's carcinogenesis.
Authors:
Bernardo Silveira Volkweis; Richard Ricachenevsky Gurski; Luise Meurer; Guilherme Gonçalves Pretto; Guilherme da Silva Mazzini; Maria Isabel Edelweiss
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Publication Detail:
Type:  Journal Article     Date:  2012-07-11
Journal Detail:
Title:  Gastroenterology research and practice     Volume:  2012     ISSN:  1687-630X     ISO Abbreviation:  Gastroenterol Res Pract     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-08-23     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  101475557     Medline TA:  Gastroenterol Res Pract     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  639748     Citation Subset:  -    
Affiliation:
Department of Surgery, Hospital de Clínicas de Porto Alegre, School of Medicine, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil.
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