| Ki-1-positive cutaneous large cell lymphoma of T cell type: report of an indolent subtype. | |
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MedLine Citation:
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PMID: 2536763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T cell lymphomas that demonstrate skin involvement include not only mycosis fungoides and Sézary syndrome but also a wide variety of other T cell neoplasms. Whether any specific clinicopathologic associations exist for nonmycosis fungoides/Sézary syndrome cutaneous T cell lymphomas is not known, and whether they represent distinct entities or a spectrum of a similar disease process also is not known. We describe a patient with a localized cutaneous large cell lymphoma with a Ki-1-positive "aberrant" T helper/inducer phenotype. Clonal rearrangement of the T cell receptor gene was documented. Although these histologic characteristics and immunophenotype are usually associated with high-grade lymphomas, the patient appears clinically to have a much less aggressive neoplasm. The possible relationship of this overt lymphoma to lymphomatoid papulosis is discussed. |
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Authors:
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J S Lindholm; D R Barron; M E Williams; S H Swerdlow |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 20 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-03-17 Completed Date: 1989-03-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 342-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Minnesota, College of Medicine, Minneapolis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD30 Antigens, Differentiation / analysis*, genetics Antigens, Neoplasm / analysis*, genetics Biopsy DNA, Neoplasm / analysis Humans Lymphoma / analysis, immunology*, pathology Male Middle Aged Phenotype Skin Neoplasms / analysis, immunology*, pathology T-Lymphocytes, Helper-Inducer / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD30; 0/Antigens, Differentiation; 0/Antigens, Neoplasm; 0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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