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Khorasan Disease: Prevalence of HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) In West Azarbaijan from 2004 to 2007.
MedLine Citation:
PMID:  22737507     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Because of the low prevalence of Human T Lymphotropic Virus type I (HTLV-I) in comparison with Khorasan Province, considering HTLV-I as an etiology of spastic paraparesia, it may be neglected in evaluation of spastic paraparesis in the other regions of Iran. Some reports of spastic paraparetic patients due to HTLV-I infection in West Azarbaijan, caused us to reconsider the importance of HTLV-I epidemiology in the other areas of the country.
METHODS: All spastic paraparetic patients who referred to Motahari and Imam Khomeini educational hospitals of Urmia from September 2004 to September 2007 were assessed for HTLV-I infection antibodies.
RESULTS: In our 3 years study, 11 cases were diagnosed as Human T Lymphotropic Virus type I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP, 2 males and 9 females).The mean age of patients at the time of diagnosis was 45.8 years. Dorsal and cervical MRI of all patients was normal. Serum Enzyme-Linked Immuno-Sorbent Assay (ELISA) and Western blot (WB) for anti HTLV-I antibody in all patients was positive. Four patients underwent for lumbar puncture in which were normal in respect of cells and biochemistry, but positive for anti-HLTLV-I antibodies.
CONCLUSION: HAM/TSP detection in West Azarbaijan in spite of its long distance from Khorasan Province shows the importance of anti-HTLV-I Ab assay in the blood and CSF of every spastic paraparetic patient all over the country.
Authors:
R Boostani; A Mellat Ardakani; H Ashrafi
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Publication Detail:
Type:  Journal Article     Date:  2011-06-01
Journal Detail:
Title:  Iranian Red Crescent medical journal     Volume:  13     ISSN:  2074-1812     ISO Abbreviation:  Iran Red Crescent Med J     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2012-06-27     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101319850     Medline TA:  Iran Red Crescent Med J     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  428-30     Citation Subset:  -    
Affiliation:
Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran.
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