Document Detail


Key role of L-alanine in the control of hepatic protein synthesis.
MedLine Citation:
PMID:  3593204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of administration of single amino acids to starved rats on the regulation of protein synthesis in the liver. Of all the amino acids tested, only alanine, ornithine and proline promoted statistically significant increases in the extent of hepatic polyribosome aggregation. The most effective of these was alanine, whose effect of promoting polyribosomal aggregation was accompanied by a decrease in the polypeptide-chain elongation time. The following observations indicate that alanine plays an important physiological role in the regulation of hepatic protein synthesis. Alanine was the amino acid showing the largest decrease in hepatic content in the transition from high (fed) to low (starved) rates of protein synthesis. The administration of glucose or pyruvate is also effective in increasing liver protein synthesis in starved rats, and their effects were accompanied by an increased hepatic alanine content. An increase in hepatic ornithine content does not lead to an increased protein synthesis, unless it is accompanied by an increase of alanine. The effect of alanine is observed either in vivo, in rats pretreated with cycloserine to prevent its transamination, or in isolated liver cells under conditions in which its metabolic transformation is fully impeded.
Authors:
D Pérez-Sala; R Parrilla; M S Ayuso
Related Documents :
15921824 - Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammo...
16661904 - Amino acid synthesis in photosynthesizing spinach cells : effects of ammonia on pool si...
16487314 - The occurrence of free d-alanine and an alanine racemase activity in leishmania amazone...
25466904 - Small-intestinal or colonic microbiota as a potential amino acid source in animals.
18855594 - Novel ph-sensitive interpenetrating network hydrogel beads of carboxymethylcellulose-(p...
7532094 - Changes in monoamine turnover in forebrain areas associated with masculine sexual behav...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  241     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-07-10     Completed Date:  1987-07-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  491-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alanine / metabolism*
Amino Acids / blood,  pharmacology
Animals
Glucose / pharmacology
Liver / drug effects,  metabolism*
Male
Peptide Chain Elongation, Translational / drug effects
Polyribosomes / metabolism
Protein Biosynthesis*
Pyruvates / pharmacology
Pyruvic Acid
Rats
Rats, Inbred Strains
Starvation / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Pyruvates; 127-17-3/Pyruvic Acid; 50-99-7/Glucose; 56-41-7/Alanine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ketone-body metabolism after surgical stress or partial hepatectomy. Evidence for decreased ketogene...
Next Document:  Structural and functional effects of selective chemical modifications of Scapharca inaequivalvis hae...