Document Detail

Key questions and answers about pregnancy-associated plasma protein-A.
MedLine Citation:
PMID:  22463950     Owner:  NLM     Status:  MEDLINE    
Twenty-five years after it was identified as a circulating protein of unknown function derived from the placenta, pregnancy-associated plasma protein-A (PAPP-A) was discovered to be a novel zinc metalloproteinase expressed by a variety of cell types. Great progress has been made in understanding the biology of PAPP-A and its regulation during recent years, especially in regard to physiological and pathophysiological inflammatory injury responses. However, much remains to be learned about this complex protein and its potential clinical implications outside pregnancy. In this article we address some of the outstanding questions about PAPP-A, in particular about its newly emerging role in the insulin-like growth factor (IGF) system.
Cheryl A Conover
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-28
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  23     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-09-07     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  242-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Pregnancy-Associated Plasma Protein-A / genetics,  metabolism*
Somatomedins / genetics,  metabolism*
Grant Support
AG028141/AG/NIA NIH HHS; HL074871/HL/NHLBI NIH HHS; R01 AG028141/AG/NIA NIH HHS; R01 AG028141-01A1/AG/NIA NIH HHS; R01 AG028141-02/AG/NIA NIH HHS; R01 AG028141-03/AG/NIA NIH HHS; R01 AG028141-04/AG/NIA NIH HHS; R01 AG028141-05/AG/NIA NIH HHS; R01 HL074871/HL/NHLBI NIH HHS; R01 HL074871-01/HL/NHLBI NIH HHS; R01 HL074871-02/HL/NHLBI NIH HHS; R01 HL074871-03/HL/NHLBI NIH HHS; R01 HL074871-04/HL/NHLBI NIH HHS; R01 HL074871-05/HL/NHLBI NIH HHS; R01 HL074871-06/HL/NHLBI NIH HHS; R01 HL074871-07/HL/NHLBI NIH HHS; R01 HL074871-08/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Somatomedins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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