Document Detail


Key factors for best control of the systemic leakage during hyperthermic isolated limb perfusion (HILP) in ECC. A critical synthesis of our experience.
MedLine Citation:
PMID:  18365536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The L-PAM-ILP procedures under true hyperthermal regime (41.5-41.8 degrees C) require both close control of the physical parameters of the treatment (temperatures profiles and time duration, artero-venous pressure, perfusate flow rate) and medical rationale (drug, dosage, fractioning, timing). All the above essential procedures must be supported by rigorous methodology, reliable operation of the medical devices and apparatus and real-time monitoring of the treatment parameters. Real-time monitoring is essential for proper trimming and modulation of the parameters during treatment. This paper delineates the technical improvements that we have implemented for drug leakage monitoring and control in the systemic circulation aimed at improving the therapeutic efficacy and at reducing the occurrence of unexpected complications.
Authors:
M Pace; L Millanta; R Gattai; M Matteini; L Vaggelli; E Macera Mascitelli; P Bechi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  26     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  433-42     Citation Subset:  IM    
Affiliation:
Dept. of Medical and Surgical Critical Care, University of Florence, Regional Reference Centre of Tuscany for Locoregional Perfusional Therapies in Oncology, Italy. mpace@unifi.it
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MeSH Terms
Descriptor/Qualifier:
Chemotherapy, Cancer, Regional Perfusion*
Extracorporeal Circulation
Extremities / blood supply*
Humans
Hyperthermia, Induced
Perfusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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