Document Detail


The Key Events Dose-Response Framework: a foundation for examining variability in elicitation thresholds for food allergens.
MedLine Citation:
PMID:  19690998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food allergies are caused by immunological reactions in individuals sensitized to normal protein components of foods. For any given sensitized individual, the severity of a reaction is generally assumed to be proportional to the dose of allergenic protein. There is substantial clinical evidence that "threshold" doses exist for the elicitation of an allergic reaction; however, the threshold (i.e., lowest dose that elicits a reaction) varies substantially across the sensitized population. Current approaches to protecting sensitized individuals from exposure to food allergens are highly qualitative (i.e., they rely on food avoidance). The Key Events Dose-Response Framework is an analytical approach for refining understanding of the biological basis of the dose-response. Application of this approach to food allergy provides a foundation for a more rigorous quantitative understanding of variability in allergic response. This study reviews the allergic disease process and the current approaches to identifying thresholds for food allergens. The pathway of key biological events occurring between food intake and allergic response is considered, along with factors that may determine the nature and severity of response to food allergens. Data needs, as well as implications for identifying thresholds, and for characterizing variability in thresholds, are also discussed.
Authors:
Steve L Taylor; Steven M Gendel; Geert F Houben; Elizabeth Julien
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical reviews in food science and nutrition     Volume:  49     ISSN:  1549-7852     ISO Abbreviation:  Crit Rev Food Sci Nutr     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-19     Completed Date:  2009-11-04     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8914818     Medline TA:  Crit Rev Food Sci Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-39     Citation Subset:  IM    
Affiliation:
Food Allergy Research and Resource Program, Dept. of Food Science & Technology, University of Nebraska, Lincoln, NE, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Allergens / adverse effects*
Dose-Response Relationship, Immunologic
Food Hypersensitivity*
Humans
Public Health
Chemical
Reg. No./Substance:
0/Allergens
Comments/Corrections

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